Introduction: Although there are several ways to relief pain in metastatic patients, the use of radionuclides is one of the known and effective ways to relieve the pain caused by bone metastases. The purpose of this study was to assessment of radiation dose distribution of different radioisotopes used to treatment and pain relief patients in a bone-based model based on Monte C...

BACKGROUND The alpha-emitting nuclide 211At is of great interest for radionuclide therapy when coupled to a tumor-targeting biomolecule, e.g. epidermal growth factor (EGF) the receptors of which are overexpressed in many malignancies. However, almost no information concerning the cellular processing of astatinated targeting agents is available. MATERIALS AND METHODS We indirectly astatinated ...

INTRODUCTION Prostate specific membrane antigen (PSMA) has become an attractive diagnostic and therapeutic target for small molecule ligands. Radionuclide-chelating ligands can be labeled with either 68Ga for positron-emission-tomography (PET) or 177Lu for radionuclide therapy. Areas covered: In this literature review we evaluate the diagnostic value of 68Ga PSMA PET/CT and the therapeutic pote...

Recurrent prostate cancer presents a challenge to conventional treatment, particularly so to address micrometastatic and small-volume disease. Use of α-radionuclide therapy is considered as a highly effective treatment in such applications due to the shorter range and exquisite cytotoxicity of α-particles as compared with β-particles. (213)Bi is considered an α-emitter with high clinical potent...

We present the case of a 60-year-old man with metastatic neuroendocrine tumor of the ileum following ileal resection, being evaluated for 177Lu-based peptide receptor radionuclide therapy. 68Ga-DOTANOC PET/CT showed focal increased tracer uptake in the scrotal region without any morphologic changes on the corresponding CT images. Similar increased tracer uptake was seen on...

Received 4/21/2003; revised 05/23/2003; accepted 5/30/2003. For correspondence or reprints contact: Wen-Sheng Huang, M.D., Department of Nuclear Medicine, Tri-Service General Hospital, 325, Section 2, Cheng-Kung Road, Taipei, Taiwan, R.O.C. Tel: (886)2-87927216, Fax: (886)2-87927217, E-mail: [email protected] The Na/I symporter (NIS) is the membrane protein mediating iodide translocation ...