Nonfocal liver biopsy may be required to diagnose or stage diffuse parenchymal dis• ease such as cirrhosis, viral hepatitis, autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, hemachromatosis, and Wilson’s disease. Focal liver biopsy may be necessary to diagnose or stage primary or secondary hepatic • malignancy and to differentiate malignancy from benign hepatic m...