PURPOSE Evaluation of tolerance, toxicity, and feasibility of combining large fraction (5 Gy) radiotherapy with 2-deoxy-D-glucose (2DG), an inhibitor of glucose transport and glycolysis, which has been shown to differentially inhibit repair of radiation damage in cancer cells. METHODS AND MATERIALS Twenty patients with supratentorial glioma (Grade 3/4), following surgery were treated with fou...

High energy particle radiations induce severe microstructural damage in metallic materials. Nanoporous materials with a giant surface-to-volume ratio may alleviate radiation damage in irradiated metallic materials as free surface are defect sinks. Here we show, by using in situ Kr ion irradiation in a transmission electron microscope at room temperature, that nanoporous Au indeed has significan...

Magnetic resonance imaging (MRI) is being rapidly integrated for cancer treatments-such systems are referred to as MRI-guided radiation therapy (MRIgRT). As the magnet of an MRI scanner is always on, the presence of a strong static magnetic field from the MRI scanner during radiotherapy delivery presents new challenges. One of the challenges is that a personal radiation dosimeter used to estima...

The combination of high strength and high radiation damage tolerance in nanolaminate composites can be achieved when the individual layers in these composites are only a few nanometers thick and therefore these materials contain a large volume fraction associated with interfaces. These interfaces act both as obstacles to slip, as well as sinks for radiation-induced defects. The morphological an...

OBJECT Dose-volume data concerning the brainstem in stereotactic radiosurgery (SRS) for trigeminal neuralgia (TN) were analyzed in relation to associated complications. The authors present their set of data and compare it with currently cited information on brainstem dose tolerance associated with conventional fractionated radiation therapy and hypofractionated radiation treatment of other dise...

FPGA has found an increasingly wide utilization in automatic train control (ATC) equipment used in highspeed rail systems, which is potentially sensitive to radiation. How the space radiation caused by Geomagnetic storm affects FPGA devices was analyzed. This paper investigated the FPGA fault-tolerance techniques used nowadays and presented a new mitigation technique against upsets, duplication...

This paper compares the radiation-induced soft-error tolerance effectiveness of five different attitude estimation (AE) processing approaches that are classically used in inertial navigation systems (INS) autonomous things. Results 14-MeV neutron and thermal radiation testing campaigns indicate all AE investigated can be critically perturbed by single event upsets (SEUs), yielding inappropriate...

A new generation of synchrotron radiation light sources covering the VUV, soft x-ray, and hard x-ray speclrai regions is under construction in several countries. These sources are designed specifically to use periodic magnetic undulators and low-emittance electron or positron beams to produce high-brightness near-diffraction-limited synchrotron radiation beams. Some of the novel features of the...

This paper comparatively analyzes the static random-access memory (SRAM) cell designs for fault tolerance. Since SRAM cells are sensitive to radiation-induced single event upsets, various circuit-level approaches have been applied. Compared conventional circuits, one possibility is adding redundant storage nodes by means of additional transistors. The strength and weakness in terms performance ...