PURPOSE The effect of ZD6126 on tumor oxygen tension and tumor growth delay in combination with ionizing radiation was examined in the human U87 glioblastoma tumor model. Resistance to ZD6126 treatment was investigated with the nitric oxide synthase inhibitor, l-N(G)-nitroarginine methyl ester (hydrochloride; l-NAME/active form, l-NNA). METHODS U87 human xenografts were grown in athymic nude ...

Chronic radiation dermatitis is a late side effect of skin irradiation, which may deteriorate patients' quality of life. There is a lack of precise data about its incidence; however, several risk factors may predispose to the development of this condition. It includes radiotherapy dose, fractionation, technique, concurrent systemic therapy, comorbidities, and personal and genetic factors. Chron...

Harvard Medical School, Boston, Massachusetts Department of Neurosurgery, Dana-Farber/Brigham & Women’s Cancer Center, Boston, Massachusetts Department of Pathology, Dana-Farber/Brigham & Women’s Cancer Center, Boston, Massachusetts York Hospital Oncology, York, Maine Department of Medical Oncology, Dana-Farber/Brigham & Women’s Cancer Center, Boston, Massachusetts Department of Radiation Oncol...

Cerebral necrosis after radiation therapy of extracranial neoplasms is an infrequent but well-documented complication [1-5]. CT and MR findings associated with changes caused by radiation therapy have been reported; however, differentiating changes caused by irradiation from postoperative changes and recurrent tumor may not always be possible because the·CT and MR findings are nonspecific [6-8]...

The treatment of delayed radiation injuries (soft tissue and bony radiation necrosis) is one of thirteen conditions approved by the Hyperbaric Oxygen Therapy Committee of the Undersea and Hyperbaric Medical Society as appropriate indications for hyperbaric oxygen (HBO2). This paper provides a systematic review of the literature reporting the results of HBO2 therapy in the treatment and/or proph...