The catalytic synthesis of peptides is a major challenge in the modern organic chemistry hindered by the well-established use of stoichiometric coupling reagents. Herein, we describe for the first time that borinic acid is able to catalyse this reaction under mild conditions with an improved activity compared to our recently developed thiophene-based boronic acid. This catalyst is particularly ...

The first catalytic asymmetric addition of ynamides to aliphatic and aromatic aldehydes is described. This reaction provides unprecedented access to a diverse family of N-substituted propargylic alcohols that are obtained in high yield and ee in the presence of 10 mol% of zinc triflate and N-methylephedrine. The use of apolar solvent mixtures is essential to avoid product racemization and to op...

Abstract Background Age estimation is a vital aspect of the identification an individual in forensic science. Teeth are one toughest structures human body and generally survive postmortem destruction. So, they can therefore be used more reliably than any other morphological or histological trait adult skeleton for estimating age. Aim study The present work aimed to compare cementum incremental ...