The increased use of fluoroquinolones has led to increasing resistance to these antimicrobials, with rates of resistance that vary by both organism and geographic region. Resistance to fluoroquinolones typically arises as a result of alterations in the target enzymes (DNA gyrase and topoisomerase IV) and of changes in drug entry and efflux. Mutations are selected first in the more susceptible t...

Trovafloxacin was found to be a typical quinolone producing a biphasic dose response against Escherichia coli, Staphylococcus aureus or Streptococcus pneumoniae. A reduced rate of kill was seen against Enterococcus faecalis, which is also typical of the quinolones. However, the bactericidal activity of trovafloxacin against S. aureus and S. pneumoniae was greater than most other quinolones prev...

ABSTRACT Background and Objectives: One major source of antibiotic contamination in the sea is from aquaculture. We monitored concentration commonly used classes resistance genes ( tet (M), sul1, sul2 sul3 ) aquaculture farms Peninsular Malaysia. Methods: Antibiotic residues were quantified using high-performance liquid chromatography real-time PCR respectively. Risk quotients European technica...

Quinolones are potent antibacterial agents that specifically target bacterial DNA gyrase and topoisomerase IV. Widespread use of these agents has contributed to the rise of bacterial quinolone resistance. Previous studies have shown that quinolone resistance arises by mutations in chromosomal genes. Recently, a multiresistance plasmid was discovered that encodes transferable resistance to quino...

INTRODUCTION Diabetes mellitus and the postmenopausal period are associated with increased risk of urinary tract infections (UTIs) in women. However, data on UTIs in postmenopausal diabetic women are scarce. OBJECTIVES The aim of this study was to determine the prevalence of UTIs in postmenopausal women with type 2 diabetes mellitus, identify the potential risk factors, describe the causative p...

The article presents the results of validation screening method for determination quinolone antibiotics residues (enrofloxacin, ciprofloxacin, marbofloxacin, danofloxacin) in tissue samples, egg powder, milk and blood plasma using RIDASCREEN®Chinolone/Quinolones test kits from R-Biopharm (Germany). According to information provided by manufacturer kit, quantitative quinolones content can be car...