warded as a promising molecule because of its broad spectrum pharmacological activities like antitubercular, antibacterial, antifungal, anticancer, anti-HIV, anthelmintic, anti-inflammatory and antihypertensive activities. Imidazoles are one of the oldest and potent heterocyclic compounds having antimicrobial activities. Structure activity relationship studies of quinazolinone ring system revea...

A rapid, simple, accurate, and precise isothermal gas-chromatographicmethod is introducedfor determination of methaqualone (2-methyl-3-o-tolyl4(3H)-quinazolinone) in serum. A single extraction of 2 ml of serum, without derivative formation, will give adequate sensitivity for quantitation of therapeutic serum concentrations of the drug within 15 mm. The method is free of interferences from biolo...

Quinazolinones are a group of fused heterocyclic compounds which have valuable biological properties including cytotoxic, antibacterial and antifungal activities. Thiazole group-containing compounds have been also reported to have a wide range of biological activities such as antitumor, anti-inflammatory, analgesic and antibacterial effects. Due to valuable cytotoxic effects of both thiazole gr...

2-(6,8-Dibromo-2-methylquinazolin-4-yloxy)-acetohydrazide (4) was prepared by the reaction of 6,8-dibromo-2-methylbenzo-[d][1,3]oxazin-4-one with formamide to afford quinazolinone 2, followed by alkylation with ethyl chloroacetate to give the ester 3. Treatment of ester 3 with hydrazine hydrate and benzaldehyde afforded 4 and styryl quinazoline 5. The hydrazide was reacted with triethyl orthofo...