Transcatheter aortic valve replacement (TAVR) is a transformative innovation that provides treatment for high or prohibitive surgical risk patients with symptomatic severe aortic stenosis who either were previously not referred for or were denied operative intervention. Trials have demonstrated improvements in survival and symptoms after TAVR versus medical therapy; however, there remains a siz...

This piece examines the parallels between one-shot library instruction and one-off equity, diversity, inclusion (EDI) workshops. Library Information Science/Studies (LIS) as a field problematically frames both information literacy EDI add-ons or afterthoughts to work of workers. framing tells on itself when field/profession turns one-shots, workshops, other band aid solutions larger systemic st...

Interview with Spanish psychotherapist Rafael Santandreu, about various subject-matters: among them, his education, vocation, and professional career; the futility of progress; relevance Classical culture philosophy; desirability a Cynical attitude for fighting social preconceptions; need rationalizing in face apparent misfortunes.
 Keywords psychology, philosophy, Stoicism, education.

We report a 17-year-old woman with bronchiolitis obliterans-organizing pneumonia (BOOP)-like granulomatosis with polyangiitis developing severe airway obliterations. Pending age, phase and grade of autoimmune treatment, and offering ECMO treatment may be crucial for survival but occasionally preface futility. ECMO-treated patient with BOOP-like GPA has never been described before.

Chasing HIV-1 across the genotype landscape, unequipped to anticipate its maneuvers, the antibody variable-region genes pursue the virus in futility. In this issue of Cell Host & Microbe, Dingens et al. (2017) exhibit a powerful technology that reveals the escape pathways of HIV-1 and may enable its capture.

Pre-specified interim analyses may be performed to evaluate whether a clinical trial can be halted prematurely for overwhelming efficacy and/or futility. This approach is somewhat more complex when the primary endpoint is a survival analysis. This paper provides an overview of performing the initial calculations and actual interim analyses using SAS ® PROC SEQDESIGN and PROC SEQTEST, EAST ® sof...

Acceptance of the concept of medical futility facilitates a paradigm shift from curative to palliative medicine, accommodating a more humane approach and avoiding unnecessary suffering in the course of the dying process. This should not be looked upon as abandoning the patient but rather as providing the patient and family with an opportunity to come to terms with the dying process. It also doe...