Mutated KRAS promotes the activation of MAPK pathway and progression colorectal cancer (CRC) cells. Aberrant PI3K strongly attenuates efficacy suppression in KRAS-mutated CRC. The development a novel strategy targeting dual is therefore highly essential for therapy In this study, quadruple-depleting system KRAS, MEK1, PIK3CA, MTOR genes based on CRISPR/SaCas9 was developed. Adenovirus serotype ...

BACKGROUND Several large clinical trials and meta-analyses have shown about 20% failure to eradicate Helicobacter pylori (H.pylori), necessitating investigations for second-line treatments. The aim of this study was to evaluate the effects of clarithromycin-containing quadruple regimen after nitroimidazole-containing quadruple therapy failure. METHODS Thirty two patients who had failed 10-day H...

Aims. We aim to increase the contrast limits detect new satellites orbiting known asteroids. use cutting-edge data reduction techniques and processing algorithms that are essential best analyse raw provided by instruments their performances. Doing so, unequalled performances of SPHERE also make it a unique tool resolve study asteroids in solar system, expanding domain its main science targets. ...

BACKGROUND Furazolidone has recently shown promising efficacy in H. pylori eradication and has replaced metronidazole in different eradication regimens especially in countries, like Iran, with high prevalence of metronidazole resistance and where clarithromycin is expensive and hardly available. This study tries to determine the efficacy of a quadruple therapy based on furazolidone as a second ...