نتایج جستجو برای: pyruvates

تعداد نتایج: 6535  

2012
Yasuoki MURAKAMI

We found that the Fischer indole synthesis of ethyl pyruvate 2-methoxyphenylhydrazone (5) with HCl/EtOH gave an abnormal product, ethyl 6-chloroindole-2-carboxylate (7), as the main product, with a smaller amount of ethyl 7-methoxyindole-2-carboxylate (6) as the normal product. This abnormal reaction was the result of a cyclization on the side with the substituent (methoxy group) of a benzene r...

Journal: :The Biochemical journal 1985
P Schadewaldt E Lammers W Staib

The effects of insulin and glucose on the oxidative decarboxylation of pyruvate in isolated rat hindlimbs was studied in non-recirculating perfusion with [1-14C]pyruvate. Insulin increased the calculated pyruvate decarboxylation rate in a concentration-dependent manner. At supramaximal insulin concentrations, the calculated pyruvate decarboxylation rate was increased by about 40% in perfusions ...

Journal: :The Journal of Cell Biology 1969
Alexandra von der Decke

The increase in the incorporation of amino acids into protein in vitro by preparations obtained from protein-fed rats as compared with preparations obtained from carbohydrate-fed rats has been described previously. After molecular sieving through Sephadex G-25 of cell-free preparations, the difference in incorporating activity between the two types of rats was diminished in systems containing A...

Journal: :Anesthesiology 2012
Alexander Zlotnik Igor Sinelnikov Benjamin F Gruenbaum Shaun E Gruenbaum Michael Dubilet Elena Dubilet Akiva Leibowitz Sharon Ohayon Adi Regev Matthew Boyko Yoram Shapira Vivian I Teichberg

BACKGROUND Decreasing blood glutamate concentrations after traumatic brain injury accelerates brain-to-blood glutamate efflux, leading to improved neurologic outcomes. The authors hypothesize that treatment with blood glutamate scavengers should reduce neuronal cell loss, whereas administration of glutamate should worsen outcomes. The authors performed histologic studies of neuronal survival in...

Journal: :Biochemistry 2013
Kathrin Schröder-Tittmann Danilo Meyer Johannes Arens Cindy Wechsler Michael Tietzel Ralph Golbik Kai Tittmann

Thiamin diphosphate (ThDP)-dependent enzymes play vital roles in cellular metabolism in all kingdoms of life. In previous kinetic and structural studies, a communication between the active centers in terms of a negative cooperativity had been suggested for some but not all ThDP enzymes, which typically operate as functional dimers. To further underline this hypothesis and to test its universali...

Journal: :International Journal of Biological Sciences 2005
Ikram-ul Haq Sikander Ali M.A. Qadeer

In this paper we report the regulation of Aspergillus niger growth rate during citric acid fermentation in a stirred tank bioreactor. For this, the influence of dissolved oxygen concentration in a medium on intracellular pH values and consequently on overall microbial metabolism was emphasized. Intracellular pH of mycelium grown under different concentrations of dissolved oxygen in the medium w...

2011
Jens Niklas Eva Schräder Volker Sandig Thomas Noll Elmar Heinzle

For the improved production of vaccines and therapeutic proteins, a detailed understanding of the metabolic dynamics during batch or fed-batch production is requested. To study the new human cell line AGE1.HN, a flexible metabolic flux analysis method was developed that is considering dynamic changes in growth and metabolism during cultivation. This method comprises analysis of formation of cel...

Journal: :The Biochemical journal 1993
L Agius D Tosh M Peak

1. During conversion of [6-3H,U-14C]glucose to glycogen in liver, loss of 6-3H can occur either by cycling via pyruvate (between glycolysis and gluconeogenesis) or by other mechanisms. We used mercaptopicolinate, an inhibitor of phosphoenolpyruvate carboxykinase, to determine the extent to which pyruvate cycling contributes to loss of 6-3H during glucose conversion to glycogen in hepatocytes. 2...

Journal: :Structure 2008
Masato Kato R Max Wynn Jacinta L Chuang Shih-Chia Tso Mischa Machius Jun Li David T Chuang

We report the crystal structures of the phosporylated pyruvate dehydrogenase (E1p) component of the human pyruvate dehydrogenase complex (PDC). The complete phosphorylation at Ser264-alpha (site 1) of a variant E1p protein was achieved using robust pyruvate dehydrogenase kinase 4 free of the PDC core. We show that unlike its unmodified counterpart, the presence of a phosphoryl group at Ser264-a...

Journal: :Cancer research 1968
A Caputo A Floridi

SUMMARY Some metabolic properties of a new, spontaneous, trans plantable adenocarcinoma originating from a C3H mouse sub maxillary gland have been analytically compared to the normal gland. The major findings may be summarized as follows: (a) The oxygen consumption of tumor cells is 38% higher than that of the normal gland. (b) In anaerobic conditions the nor mal submaxifiary gland shows a high...

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