نتایج جستجو برای: pyrogenic process
تعداد نتایج: 1313404 فیلتر نتایج به سال:
Acute rheumatic fever (ARF), a sequelae of group A Streptococcus (GAS) infection, is the most common cause of preventable childhood heart disease worldwide. The molecular basis of ARF and the subsequent rheumatic heart disease are poorly understood. Serotype M18 GAS strains have been associated for decades with ARF outbreaks in the U.S. As a first step toward gaining new insight into ARF pathog...
The cytokine IL-6, which is released upon peripheral immune challenge, is critical for the febrile response, but the mechanism by which IL-6 is pyrogenic has remained obscure. Here we generated mice with deletion of the membrane bound IL-6 receptor α (IL-6Rα) on neural cells, on peripheral nerves, on fine sensory afferent fibers, and on brain endothelial cells, respectively, and examined its ro...
Site-specific modulation of LPS-induced fever and interleukin-1 expression in rats by interleukin-10
Ledeboer, Annemarie, Rob Binnekade, John J. P. Brevé, John G. J. M. Bol, Fred J. H. Tilders, and AnneMarie Van Dam. Site-specific modulation of LPS-induced fever and interleukin-1 expression in rats by interleukin-10. Am J Physiol Regulatory Integrative Comp Physiol 282: R1762–R1772, 2002. First published February 7, 2002; 10.1152/ajpregu.00766.2001.—Bacterial lipopolysaccharide (LPS) induces f...
Streptococcal pyrogenic exotoxin A (SPE A) is secreted by some strains of Streptococcus pyogenes and is strongly associated with streptococcal toxic shock syndrome (STSS), a severe and often fatal illness. SPE A possesses a number of biological properties, some of which are shared with a group of exotoxins of streptococcal and staphylococcal origins, the pyrogenic toxin superantigens (PTSAgs). ...
Recently, it has been shown that the Toll-like receptors-2 and -6 agonist fibroblast-stimulating lipopeptide-1 (FSL-1) have the capacity to induce fever and sickness behavior in rats. Since the mechanisms of the fever-inducing effects of FSL-1 are still unknown, we tested the pyrogenic properties of FSL-1 in guinea pigs and assessed a role for TNF-alpha and prostaglandins in the manifestation o...
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