Chain-extended ureido-pyrimidinone poly(ethylene glycol) (CE-UPy-PEG) is a supramolecular hydrogel with excellent mechanical properties and shape memory capabilities, making it highly suitable for 3D printing of complex biomimetic structures to mimic biomaterials. However, its transient hygroexpansion response under environmental change, specifically relative humidity (RH), which strongly affec...

In this research, Cu-phthalocyanine coated hybrid magnetic nanoparticles have been prepared in a simple method and evaluated as an efficient catalyst in the preparation of mono- and bis-pyrano[2,3-d]pyrimidinones and mono- and bis-2-amino-4H-pyrans from the condensation reaction of 1,3-dimethylbarbituric acid or 4-hydroxycumarin with malononitrile and mono- and bis-aldehydes under ultrasoni...

Interferons (IFNs) have established activities as antivirals and inhibitors of viral and transplantable tumors. To establish whether IFNs or their inducers can affect induction of carcinogenesis in vivo, the bladder-specific carcinogen N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) was administered in the diet at 0.11 or 0.13% (w/w) to female C3H/He mice beginning at 7 weeks of age. Mice ...

Hydrogen bonds play critical roles in protein structure, stability, and function. Most hydrogen bonds in proteins are derived from their crystal structures and the use of standard covalent geometry information, because the positions of hydrogen atoms are defined only in a limited number of ultrahigh-resolution crystal structures. On the other hand, NMR structure calculations rely mostly on the ...

A microscale chemistry improvement engine: a pre-dosed microscale high-throughput experimentation additives platform enables rapid, serendipitous reaction improvement. This platform allowed one chemist to set up 475 experiments and analyze the results using MISER chromatography in a single day, thus resulting in two high-quality catalytic systems for the construction of the title compound 1. Su...