1http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1713 Vitiligo vulgaris (VV) and psoriasis vulgaris (PV) are common dermatoses, with a worldwide occurrence of 0.5–1% and 1–3%, respectively. An imbalance between effector T cells and regulatory T cells (Tregs) can result in the pathogenesis of cutaneous immune diseases. In VV, interleukin (IL)-17-producing T-helper (Th) 17 cells ...

The presence of poliovirus (PV)-specific CD4(+) T cells in individuals vaccinated against polio has been shown, but CD8(+) T-cell responses have not been described. Here, we functionally characterize the CD4(+) T-cell response and show for the first time that dendritic cells and macrophages can stimulate PV-specific CD8(+) T-cell responses in vitro from vaccinees. Both CD4(+) T and CD8(+) T cel...

The axial distribution of an organelle, the prespore vacuole (PV), previously reported absent from the prestalk region, was determined in pseudoplasmodia of varying sizes, under differing conditions of photostimulation of migration. The distribution of these organelles, determined quantitatively by electron microscopy of sections from known axial locations, was found to have a spatial pattern w...

In this issue of Blood, King et al demonstrate a novel mechanism of protection of hematopoietic stem cells by a gene that is negatively regulated by interferon signaling.3 This follows previous papers demonstrating that IFNstimulates normal hematopoietic stem cells from dormancy,4-6 which may eventually lead to depletion of the hematopoietic stem cell pool. Whether this differential effect is m...

A photovoltaic/thermal system (PV/T) was investigated experimentally using silicon carbide nanofluid as a cooling fluid. PV/T tested in Oman with 0.5 wt.% of nanoparticles terms thermophysical properties, performance parameters, and efficiencies. At 25 °C, it found that there is an increase the fluid’s thermal conductivity, density, viscosity up to 6.64%, 13%, 12%, respectively. When examining ...

Poliovirus (PV), the pathogenic agent of paralytic poliomyelitis, is the prototype of the picornavirus family. Although paralytic poliomyelitis has been nearly totally eradicated in most industrialized countries, PV continues to be an important public health problem in many developing countries. Moreover, in industrialized countries, two current concerns are the occurrence, albeit at a very low...

The metabolic activities and tissue binding of estrone (E1) and estrone sulfate (E1S) on futile cycling were examined. Desulfation of E1S in the 9000g supernatant fraction (S9) of periportal (PP) and perivenous (PV) rat hepatocytes were of similar V (2.9 +/- 1.0 and 2.4 +/- 0.9 nmol/min/mg of S9 protein), K (30.4 +/- 8.3 and 34.8 +/- 6.6 microM), and desulfation intrinsic clearances (V/K of 77 ...

Polycythemia vera (PV) is a human clonal hematological disorder. The molecular etiology of the disease has not been identified. PV hematopoietic progenitor cells exhibit hypersensitivity to growth factors and cytokines, suggesting possible abnormalities in protein-tyrosine kinases and phosphatases. By sequencing the entire coding regions of cDNAs of candidate enzymes, we identified a G:C--> T:A...

To quantify the effects of methylmercury (MeHg) on amacrine and on ON-bipolar cells in the retina, experiments were performed in MeHgexposed groups of adult trahiras (Hoplias malabaricus) at two dose levels (2 and 6 μg/g, ip). The retinas of test and control groups were processed by mouse anti-parvalbumin and rabbit anti-αprotein kinase C (αPKC) immunocytochemistry. Morphology and soma location...