Benzyl isothiocyanate (BITC), a constituent of edible cruciferous vegetables, decreases viability of cancer cells by causing apoptosis but the mechanism of cell death is not fully understood. The present study was undertaken to determine the role of Bcl-2 family proteins in BITC-induced apoptosis using MDA-MB-231 (breast), MCF-7 (breast), and HCT-116 (colon) human cancer cells. The B-cell lymph...

BACKGROUND AND AIMS Slug is an E-cadherin repressor and a suppressor of PUMA (p53 upregulated modulator of apoptosis) and it has recently been demonstrated that Slug plays an important role in controlling apoptosis. In this study, we examined whether Slug's ability to silence expression suppresses the growth of leukemia HL-60 cells and/or sensitizes leukemia HL-60 cells to adriamycin (ADR) thro...

Somatic HER2 mutations are present in 3–5% of lung cancers, which induce constitutive signaling and oncogenesis. Neratinib, an irreversible pan-HER tyrosine kinase inhibitor, has demonstrated antitumor activity across a spectrum HER2-mutated solid cancers manageable safety profile [Hyman et al. Nature 2018]. Findings from HER2-mutant cancer model suggest that neratinib is enhanced when given co...

Potentilla discolor has been used in traditional Chinese medicine for the treatment of hyperglycemia. However, the potential role of Potentilla discolor against cancer and its mode of action remain to be fully elucidated. The present study explored the apoptotic effect of methanol extract of Potentilla discolor (MEPD) in human mucoepidermoid carcinoma (MEC) cell lines of salivary glands. MEPD m...

The natural occurrence of lentiviruses closely related to feline immunodeficiency virus (FIV) in nondomestic felid species is shown here to be worldwide. Cross-reactive antibodies to FIV were common in several free-ranging populations of large cats, including East African lions and cheetahs of the Serengeti ecosystem and in puma (also called cougar or mountain lion) populations throughout North...

The PUMA project fosters the Open Access movement und aims at a better support of the researcher’s publication work. PUMA stands for an integrated solution, where the upload of a publication results automatically in an update of both the personal and institutional homepage, the creation of an entry in a social bookmarking systems like BibSonomy, an entry in the academic reporting system of the ...

MANET is a self organized network and is composed of various independent nodes connected in an arbitrary fashion. Communication over a MANET network basically occurs through some different types of communication, such as unicast and multicast. Our work is generally been focusing on two of the protocols i.e. unicast and multicast routing protocols AODV and PUMA respectively. We will be comparing...