Energy and water shortages are two major problems in the process of urban development, meeting demands for energy fresh has become key to global sustainable development. In this study, we developed a structure-based singular value decomposition (SSVD) method through incorporating techniques multi-regional input-output (MRIO), structural path analysis (SPA), (SVD) within general framework. The S...

Content-based spam filtering is a binary text categorization problem. To improve the performance of the spam filtering, feature selection, as an important and indispensable means of text categorization, also plays an important role in spam filtering. We proposed a new method, named Bi-Test, which utilizes binomial hypothesis testing to estimate whether the probability of a feature belonging to ...

In archaeal rRNAs, the isomerization of uridine into pseudouridine (Psi) is achieved by the H/ACA sRNPs and the minimal set of proteins required for RNA:Psi-synthase activity is the aCBF5-aNOP10 protein pair. The crystal structure of the aCBF5-aNOP10 heterodimer from Pyrococcus abyssi was solved at 2.1 A resolution. In this structure, protein aNOP10 has an extended shape, with a zinc-binding mo...

The prevalence of obesity and its associated comorbidities has grown to epidemic proportions in the US and worldwide. Thus, developing safe and effective therapeutic approaches against these widespread and debilitating diseases is important and timely. Activation of peroxisome proliferator-activated receptors (PPARs) α, γ, and δ through several classes of pharmaceuticals can prevent or treat a ...

Core snRNP proteins bind snRNA through the conserved Sm site, PuA(U)n>/=3GPu. While yeast U1 snRNA has three matches to the Sm consensus, the U1 3'-terminal Sm site was found to be both necessary and sufficient for U1 function. Mutation of this site inhibited pre-mRNA splicing, blocked cell division and resulted in the accumulation of two 3'-extended forms of the U1 snRNA. Cells which harbor th...