نتایج جستجو برای: ptk

تعداد نتایج: 1449  

2017
Ce Zhu Xi Yang Bangjian Zhou Lei Wang Chunguang Zhou Tingxian Ling Limin Liu Yueming Song

BACKGROUND Several studies have explored cervical kyphosis (CK) in adolescent idiopathic scoliosis (AIS) patients. However, few studies have evaluated the cervical alignment in these patients according to their coronal curve type. The aim of this study was to analyze the radiological features of cervical sagittal alignment in Lenke 1 AIS patients before and after surgery. METHODS This is a re...

Journal: :Molecular biology of the cell 2002
Anne-Marie C Yvon Jonathan W Walker Barbara Danowski Carey Fagerstrom Alexey Khodjakov Patricia Wadsworth

The reorientation of the microtubule organizing center during cell migration into a wound in the monolayer was directly observed in living wound-edge cells expressing gamma-tubulin tagged with green fluorescent protein. Our results demonstrate that in CHO cells, the centrosome reorients to a position in front of the nucleus, toward the wound edge, whereas in PtK cells, the centrosome lags behin...

2016
Gaёlle Noé Audrey Bellesoeur Audrey Thomas-Schoemann Savithri Rangarajan Faris Naji Alicja Puszkiel Olivier Huillard Nathaniel Saidu Lisa Golmard Jerome Alexandre Francois Goldwasser Benoit Blanchet Michel Vidal

BACKGROUND Sunitinib is a protein tyrosine kinase (PTK) inhibitor that has immune-modulating properties. In this context, peripheral blood mononuclear cells (PBMC), mainly constituted by lymphocytes, could be a perfect surrogate tissue for identifying and assaying pharmacodynamic biomarkers of sunitinib. In this study, we investigated the changes in lymphocytes count as pharmacodynamic biomarke...

Journal: :Cancer research 2001
M W Deininger S A Vieira Y Parada L Banerji E W Lam G Peters F X Mahon T Köhler J M Goldman J V Melo

Leukemia cells bearing the Philadelphia (Ph) chromosome express a Bcr-Abl fusion protein with deregulated protein tyrosine kinase (PTK) activity, which plays a central role in the malignant transformation. Many different signal transduction pathways are activated by Bcr-Abl, but little is known about their downstream targets in specific cell lineages. We show here that Ph-positive cell lines as...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2004
Beverley A Moore Andreas Türler Michael A Pezzone Kevin Dyer Jennifer Grandis Anthony J Bauer

Manipulation of the bowel during abdominal surgery leads to a period of ileus, which is most severely manifested after procedures that directly involve the colon. Ileus is associated with the increased expression of proinflammatory cytokines and chemokines, a leukocytic infiltration into the muscularis, and the release of mediators from resident and infiltrating leukocytes that directly inhibit...

Journal: :American journal of physiology. Cell physiology 2002
Bok Hee Choi Jin-Sung Choi Duck-Joo Rhie Shin Hee Yoon Do Sik Min Yang-Hyeok Jo Myung-Suk Kim Sang June Hahn

The action of tyrphostin AG-1478, a potent protein tyrosine kinase (PTK) inhibitor, on rat brain Kv1.5 channels (Kv1.5) stably expressed in Chinese hamster ovary cells was investigated using the whole cell patch-clamp technique. AG-1478 rapidly and reversibly inhibited Kv1.5 currents at 50 mV in a concentration-dependent manner with an IC50 of 9.82 microM. AG-1478 accelerated the decay rate of ...

1999
CHARLES W. LEFFLER

Parfenova, Helena, John Haffner, and Charles W. Leffler. Phosphorylation-dependent stimulation of prostanoid synthesis by nigericin in cerebral endothelial cells. Am. J. Physiol. 277 (Cell Physiol. 46): C728–C738, 1999.— Nigericin decreases intracellular pH (pHi) and stimulates prostanoid (PG) synthesis in endothelial cells from cerebral microvessels of newborn pigs. Nigericin-induced PG produc...

Journal: :Clinical and vaccine immunology : CVI 2008
Heather MacLeod Navneet Bhasin Lee M Wetzler

Neisserial porins are potent immune adjuvants and have been demonstrated to stimulate and induce the activation of human and murine B lymphocytes. Their immunopotentiating ability is due largely to the upregulation of the surface expression of the costimulatory ligand CD86 (B7-2) on B cells and other antigen-presenting cells. Porin-induced activation is dependent on the innate immune pattern re...

Journal: :American journal of physiology. Renal physiology 2001
O Kifor R J MacLeod R Diaz M Bai T Yamaguchi T Yao I Kifor E M Brown

Regulation of the extracellular signal-regulated kinase 1 and 2 (ERK1/2) pathway by the extracellular calcium (Ca2+o)-sensing receptor (CaR) was investigated in bovine parathyroid and CaR-transfected human embryonic kidney (HEKCaR) cells. Elevating Ca2+o or adding the selective CaR activator NPS R-467 elicited rapid, dose-dependent phosphorylation of ERK1/2. These phosphorylations were attenuat...

Journal: :ABDIPRAJA 2023

Kegiatan pengabdian kepada masyarakat ini dilatarbelakangi adanya permasalahan mitra, yaitu kurangnya pemahaman dan kompetensi guru dalam merencanakan, melaksanakan, melaporkan Penelitian Tindakan Kelas (PTK). Program kemitraan bertujuan untuk meningkatkan melaksanakan (PTK) menulis hasil penelitian bentuk laporan PTK atau artikel ilmiah, melalui pelatihan pendampingan PTK. Pelatihan dilaksanak...

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