نتایج جستجو برای: pth

تعداد نتایج: 6804  

Journal: :The Journal of clinical investigation 1999
W Zhao M H Byrne B F Boyce S M Krane

Parathyroid hormone (PTH) stimulates bone resorption by acting directly on osteoblasts/stromal cells and then indirectly to increase differentiation and function of osteoclasts. PTH acting on osteoblasts/stromal cells increases collagenase gene transcription and synthesis. To assess the role of collagenase in the bone resorptive actions of PTH, we used mice homozygous (r/r) for a targeted mutat...

2014
Min-Gu Kang Eun-Jeong Won Hyun-Woo Choi Hye-Ran Kim Hyun-Jung Choi Hye-Ri Park Jong-Hee Shin Soon-Pal Suh Dong-Wook Ryang Myung-Geun Shin

We hypothesized that serum PTH might be associated with various clinicopathological parameters in multiple myeloma (MM). So we investigated the implications of serum PTH in MM patients and the relationship with other risk factors of MM. A total of 115 patients who were newly diagnosed with MM were enrolled. Serum PTH level was 24.7 ± 34.9 (ranged 0.0-284.1) pg/mL. Serum levels of IgG, IgM, FLC-...

Journal: :Journal of cellular biochemistry 2009
Supaporn Suttamanatwong Eric D Jensen Jody Schilling Renny T Franceschi Ann E Carlson Kim C Mansky Rajaram Gopalakrishnan

As part of its catabolic action in bone, parathyroid hormone (PTH) inhibits extracellular matrix mineralization. We previously showed that PTH dose-dependently induces matrix gla protein (MGP) expression in osteoblasts and this induction is at least partially responsible for PTH-mediated inhibition of mineralization. Recently, we identified PKA and ERK/MAPK as the key signaling pathways involve...

2017
Paula Suarez-Bregua Laura Cal Cristian Cañestro Josep Rotllant

The parathyroid hormone (PTH) family is a group of structurally-related secreted peptides involved in bone mineral homeostasis and multitude of developmental processes in vertebrates. These peptides mediate actions through PTH receptors (PTHRs), which belong to the transmembrane G protein-coupled receptor group. To date, genes encoding for PTH and PTHR have only been identified in chordates, su...

Journal: :ACS Applied Materials & Interfaces 2021

The encapsulation of an organic dye, 10-phenylphenothiazine (PTH), in the inner cavity single-walled carbon nanotubes (SWNTs) as a breaking heterogenization strategy is presented. PTH@oSWNT material was microscopically and spectroscopically characterized, showing intense photoemission when illuminated with visible light at nanoscale. Thus, employed heterogeneous photocatalyst single electron tr...

2013
Shilpa Choudhary Katherine Blackwell Olga Voznesensky Abhijit Deb Roy Carol Pilbeam

Intermittent PTH is the major anabolic therapy for osteoporosis while continuous PTH causes bone loss. PTH acts on the osteoblast (OB) lineage to regulate bone resorption and formation. PTH also induces cyclooxygenase-2 (COX-2), producing prostaglandin E2 (PGE(2)) that can act on both OBs and osteoclasts (OCs). Because intermittent PTH is more anabolic in Cox-2 knockout (KO) than wild type (WT)...

Journal: :Endocrinology 2005
Robert Gensure Harald Jüppner

In mammals, PTH is a component in a complex signaling system involving three structurally related ligands and two G protein-coupled receptors, which share significant amino acid sequence homology (Fig. 1). PTH is a peptide hormone comprising 84 amino acids that is made by the parathyroid glands (and to a much smaller extend by the thymus) and acts through the PTH/PTH-related peptide (PTHrP) rec...

Journal: :Clinical chemistry 2007
Jasper A Remijn Johan R Beukhof Lambert D Dikkeschei

To the Editor: Hyperparathyroidism is a potentially serious complication in patients with advanced renal insufficiency (1 ). As renal mass dwindles and phosphate excretion gets more difficult, synthesis of 1,25-dihydroxycholecalciferol is impaired, and concentrations of fibroblast growth factor-23 increase (2 ), leading to low serum calcium concentrations and an initially appropriate response o...

Journal: :Clinical chemistry 2000
J H Brossard R Lepage H Cardinal L Roy L Rousseau C Dorais P D'Amour

BACKGROUND Commercial intact parathyroid hormone (I-PTH) assays detect molecular form(s) of human PTH, non-(1-84) PTH, different from the 84-amino acid native molecule. These molecular form(s) accumulate in hemodialyzed patients. We investigated the importance of non-(1-84) PTH in the interpretation of the increased I-PTH in progressive renal failure. METHODS Five groups were studied: 26 heal...

Journal: :Clinical chemistry 2004
Sylvie Faucher Alexandre Martel Alice Sherring Tao Ding Laurie Malloch John E Kim Michèle Bergeron Paul Sandstrom Francis F Mandy

the observed differences between the two methods. Our study is even more intriguing if we consider that, very recently, a new molecular form of PTH, with structural integrity of the PTH(1– 4) region and a modified PTH(15–20) region, has been identified by HPLC in primary and secondary hyperparathyroidism (21). In fact, this newly discovered form of PTH appears to be immu-noreactive and detectab...

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