IMPORTANCE Hypertension is prevalent among patients with psoriasis. The effect of psoriasis and its severity on hypertension control is unknown. OBJECTIVE To determine the association between uncontrolled blood pressure and psoriasis, both overall and according to objectively measured psoriasis severity, among patients with diagnosed hypertension. DESIGN, SETTING, AND PARTICIPANTS Populatio...

Background: Psoriasis is associated with premature atherosclerosis and cardiovascular co-morbidity and mortality. Objective: To determine endothelial function in severe psoriasis at onset compared to that of matched healthy controls Methods: Using high-resolution ultrasound, we measured the diameter of brachial artery at rest, during reactive hyperemia, and after sublingual nitroglycerin. We co...

Psoriasis is a common, unpredictable, chronic immune-mediated disease characterised by skin lesions and frequently associated with arthritis. Although rarely fatal, psoriasis has a tremendous impact on a patients' quality of life. Traditional therapies for severe psoriasis include phototherapy, methotrexate, oral retinoids and cyclosporin. New biological agents add to the treatment options for ...

To evaluate the role of psoriasin, koebnerisin, interleukn (IL)-12 and IL-23 in the pathogenesis of psoriasis and their relations to Psoriasis Area Severity Index (PASI) and obesity. Thirty patients had chronic plaque psoriasis and 30 healthy subjects matched in age and sex were enrolled in this study. Serum from all subjects were used for determination of psoriasin, koebnerisin, IL-12 and IL-2...

Introduction Psoriasis is a chronic skin disorder, characterized by inflammatory and hyperproliferative processes. Globally, reports on the prevalence of psoriasis reveal major differences in terms of ethnicity and climate zone, ranging between 0 and 11.8% (Jacobson et al 2011). In Europe, psoriasis affects approximately 2-3% of the population. Psoriasis onset can occur at any age, including bi...

BACKGROUND Epidemiologic studies have provided new insights into the association between psoriasis and cardiovascular diseases. Previous population studies have examined hypertension frequency in psoriasis patients. However, the relationship between severity of hypertension and psoriasis has not been characterized. OBJECTIVE We sought to investigate whether patients with psoriasis have more d...

Introduction The role of oxidative stress in the pathogenesis of psoriasis has been investigated in previous studies with conflicting results. On the other hand, well-established treatments currently used in psoriasis exert their effects via a boost of oxidative stress. Recently, a strong positive association between psoriasis, metabolic syndrome and dyslipidemia has also been described showing...

Therapeutic agents with a putative anti-inflammatory mode of action are increasingly being pilot tested in psoriasis, a chronic inflammatory systemic disease. This is because the psoriasis patient contributes a number of advantages to trial design and execution (e.g., high disease prevalence, homogenous patient characteristics, skin manifestation that supports quick and easy quantification and ...

Multiple observational studies have demonstrated associations of psoriasis with metabolic syndrome including obesity, diabetes, hypertension, dyslipidemia, and osteoporosis. However there is paucity of Indian studies on dyslipidemia in psoriasis. The aim of this study was to assess the serum lipids in psoriasis and to investigate the association of lipids with disease severity and its duration....