STUDY QUESTION Do any proteomic biomarkers previously identified for pre-eclampsia (PE) overlap with those identified in women with polycystic ovary syndrome (PCOS). SUMMARY ANSWER Five previously identified proteomic biomarkers were found to be common in women with PE and PCOS when compared with controls. WHAT IS KNOWN ALREADY Various studies have indicated an association between PCOS and ...

Multichapter books that focus on methodology often turn out not to be fully satisfying in that most readers will find that only small parts of the books are pertinent to their interests. Although describing the methodology behind genomic and proteomic analysis is an important aspect of this book, it is nicely integrated with the pathophysiology of cardiovascular disease; thus, many readers shou...

Proteomic investigation of normal and diseased brain states has the potential to reveal novel molecular therapeutic and diagnostic targets for a multitude of pathological central nervous system conditions. Due to their unique properties, integral membrane proteins are likely to play a central role in the aetiology of these disorders. These properties, however, have prevented comprehensive analy...

High-throughput proteomic data can be used to reveal the connectivity of signaling networks and the influences between signaling molecules. We present a primer on the use of Bayesian networks for this task. Bayesian networks have been successfully used to derive causal influences among biological signaling molecules (for example, in the analysis of intracellular multicolor flow cytometry). We d...

Citation: Zhang S-F, Zhang Y, Lin L and Wang D-Z (2018) iTRAQ-Based Quantitative Proteomic Analysis of a Toxigenic Dinoflagellate Alexandrium catenella and Its Non-toxigenic Mutant Exposed to a Cell Cycle Inhibitor Colchicine. Front. Microbiol. 9:650. doi: 10.3389/fmicb.2018.00650 iTRAQ-Based Quantitative Proteomic Analysis of a Toxigenic Dinoflagellate Alexandrium catenella and Its Non-toxigen...

Bee products such as royal jelly, honey and propolis have been reported to possess several biological activities. In order to better understand their mechanism of action and, consequently, their efficiency and safety, 'omic' approaches are used. Here cases with proteomic approach are indicated. In addition to studying biological activity at a proteome level, a proteomic approach for investigati...

We propose a method for discrimination and classification of ovarian with benign, malignant and normal tissue using independent component analysis and neural networks. The method was tested for a proteomic patters set from A database, and radial basis functions neural networks. The best performance was obtained with probabilistic neural networks, resulting I 99% success rate, with 98% of specif...

Multichapter books that focus on methodology often turn out not to be fully satisfying in that most readers will find that only small parts of the books are pertinent to their interests. Although describing the methodology behind genomic and proteomic analysis is an important aspect of this book, it is nicely integrated with the pathophysiology of cardiovascular disease; thus, many readers shou...