background some herbal anticancer agents have direct interactions with dna. objectives the present study aimed to investigate the interaction of ctdna with rosemary flowers. materials and methods we used uv-vis, fluorescence and circular dichroism (cd) spectroscopic techniques. results the absorption of dna at 260 nm increased on addition of rosemary. herb extract quench the fluorescence of etb...

background: today, issues such as water shortage, difficulties and costs related to supplying safe water, and anomalous concentrations of heavy metals in groundwater and surface water resources, doubled the necessity of access to technical methods on removing these pollutants from water resources. methods: in this lab study, cationic resin purolite s-930 (with co-polymer styrene di-vinyl benzen...

Since the first successful demonstration of the tunable alignment of ubiquitin in an anisotropic liquid crystal medium only eight years ago, much progress has been made in both NMR pulse techniques for the measurements of various residual dipolar couplings (RDCs) in both proteins and nucleic acids, and applications of RDCs to many important problems in biochemistry and structural biology. In th...

In 1996 at M. Aldaz laboratory, during the study on ductal carcinoma in situ, almost 70% LOH was detected at the 16q23.3-16q24.1 region (between the D16S515 and D16S504 markers) (1). Such a high occurrence of LOH among patients with noninvasive stages of breast cancer (BC) suggested that chromosomal abnormalities in this region could be the primary changes a driving force of tumourigenesis. The...

one of the best strategies to control bacterial wilt caused by ralstonia solanacearum (smith) is generally based on breeding resistant cultivars. the information obtained from the expression of plant defense genes will provide new insight for improving plant resistance against pathogens. this study was to identify inducible genes under defense no death (dnd) reaction of tobacco (nicotiana tabac...

geometric and material nonlinear behavior of slender webs in i-column girders having stocky flanges under the action of combined lateral and axial loads is investigated. interaction curves corresponding to the application of compressive and shear loads at buckling and ultimate stages for both web plates and column sections are plotted. in addition, the effects of flange and web slenderness rati...

background: protein-protein interactions do not provide any direct information re­garding the domains within the proteins that mediate the interactions. the majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. most of the former studies focus only on interacting do­main pairs. however they do not consider the interaction...

Text mining deals with the automated annotation of texts and the extraction of facts from textual data for subsequent analysis. Such texts range from short articles and abstracts to large documents, for instance web pages and scientific articles, but also include textual descriptions in otherwise structured databases. This thesis focuses on two key problems in biomedical text mining: relationsh...

Motivation: Protein-protein complexes are known to play key roles in many cellular processes. However, they are often not accessible to experimental study because of their low stability and difficulty to produce the proteins and assemble them in native conformation. Thus, docking algorithms have been developed to provide an in silico approach of the problem. A protein-protein docking procedure ...

FCP1 [transcription factor IIF (TFIIF)-associated carboxyl-terminal domain (CTD) phosphatase] is the only identified phosphatase specific for the phosphorylated CTD of RNA polymerase II (RNAP II). The phosphatase activity of FCP1 is enhanced in the presence of the large subunit of TFIIF (RAP74 in humans). It has been demonstrated that the CTD of RAP74 (cterRAP74; residues 436-517) directly inte...