نتایج جستجو برای: protein protein interaction network analysis
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Comorbidty is common among psychiatric disorders including obsessive-compulsive disorder and schizophrenia with a high rate. Many studies suggested that the disorders may have same etiological bases. In this regard, shared pathways of glutamate, dopaminergic, and serotonin are the known ones. Here, the common significant genes are examined to understand the possible molecular origin of the diso...
background: the ability of tumour suppressor protein p53 (p53) to regulate cell cycle processes can be modulated by hepatitis b virus (hbv). while preliminary evidences indicates the involvement of protein-x of hbv (hbx) in altering p53 dna binding, no further data have been accumulated for the significance of serum p53 in chronic hepatitis b virus infected patients. methods: 72 non-cirrhotic a...
lymphomas are solid tumors of immune system and non-hodgkin lymphomas (nhl) is the most prevalent lymphomas; with wide ranges of histological and clinical features, it is so difficult to identify them. herein, various bioinformatics tools (such as gene differential expressions, epigenetics and protein analysis) employed to find new treatment approach for nhl based on gene expression variation b...
Background and purpose: The mature form of brain-derived neurotrophic factor (BDNF) binds to BDNF/NT-3 growth factors receptor (Trk-B). This binding leads to activation of Ras–MAPK pathway which is integrated with cell growth and proliferation. The BDNF deficiency is correlated with various diseases and affects aging and miscellaneous. In the present study we aimed to design a chimeric LAMP-BDN...
Drought stress-related gene identification is vital in revealing the drought resistance mechanisms underlying rice and for cultivating rice-resistant varieties. Traditional methods, such as Genome-Wide Association Studies (GWAS), usually identify hundreds of candidate stress genes, further validation by biological experiements then time-consuming laborious. However, computational prioritization...
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