Stability of the native state is an essential requirement in protein evolution and design. Here we investigated the interplay between chain length and stability constraints using a simple model of protein folding and a statistical study of the Protein Data Bank. We distinguish two types of stability of the native state: with respect to the unfolded state (unfolding stability) and with respect t...

Neurodegenerative disorders are nervous system that result in the loss of neuronal structure and function. As shown Alzheimer's Parkinson's disease, these changes cause a various capacities, including cognition mobility. Several factors have been discovered to play critical role etiology common neurological illnesses, oxidative stress protein misfolding. It's still unclear if or contribute prog...

Creutzfeldt-Jakob disease (CJD) is a rare and rapidly fatal neurological disease. Diagnosis made through clinical features, imaging, electroencephalography, cerebrospinal fluid analysis. Sporadic CJD accounts for the majority of cases occurs due to somatic mutation in gene or random structural change prion protein. Coronavirus 2019 (COVID-19) known cause neurodegeneration, acceleration hypothes...

Intrinsically disordered proteins or regions of proteins lack a well-defined structure, yet they carry out important functions often associated with the regulation of cell cycle and transcription. Due to these central roles in key cellular processes, their mutations are frequently involved in neurodegenerative diseases. These diseases are usually caused by the structural transition of disordere...

Experimental model systems have long been used to probe the causes, consequences and mechanisms of pathology leading to human disease. Ideally, such information can be exploited to inform the development of therapeutic strategies or treatments to combat disease progression. In the case of protein misfolding diseases, a wide range of model systems have been developed to investigate different asp...

Objective: Parkinson's disease, the second most common neurodegenerative disorder afflicting 10 million people worldwide and fourteenth leading cause of death in United States, is caused by dopaminergic neurons that regulate movement substantia nigra pars compacta. Mechanisms contributing to development Parkinson’s disease vulnerable individuals include protein misfolding, aggregation, mitochon...