Deregulation of a broad range protein kinases has been linked to the development and growth cancer cells. Protein are intracellular enzymes that regulate cell proliferation as well triggering regulation immune responses. important therapeutic targets in because their critical role signalling mechanisms drive malignant characteristics. Intensive efforts drug research have made this area over las...

Melanoma is a highly aggressive kind of cancer with very poor prognosis. v-Raf murine sarcoma viral oncogene homolog B1 inhibitor vemurafenib has indeed harvested substantial clinical benefits. Nevertheless, its drug resistance also hampered scientists’ efforts towards successful melanoma treatment. In this study, we used data derived from the gene expression omnibus database to analyze effect ...

background: the purpose of this study is to evaluate effects of teucrium polium (tp) leaf extracts on adenosine monophosphate activated protein kinase (ampk) level in isolated pancreases. materials and methods: in this experimental study, two groups of rats were used as a control group, and diabetic group. in the end of experimental period the animals were sacrificed then pancreas were removed,...

Under conditions favoring its autocatalytic reaction, phosphorylase kinase may be activated and phosphorylated in 2-(N-morpholino)ethanesulfonate (Mes) buffer to a much higher level than in beta-glycerophosphate buffer. The fact that the reaction is autocatalytic is supported by several observations: (a) the progress curve of the reaction exhibits a pronounced lag phase, (b) the reaction is str...

Background: Nerol was reported as a natural anti-oxidant product and its protective effects against cardiovascular diseases have been documented. Our current study designed to explore the cardioprotective effect of on hypoxia/reoxygenation (H/R)-induced production reactive oxygen species (ROS) cell apoptosis in H9c2 cells. The potential molecular mechanisms were further investigated.
 Meth...

As sessile organisms, plants possess a complex system to cope with environmental changes. Ca2+ functions as vital second messenger in the stress signaling of plants, and CBL-interacting protein kinases (CIPKs) serve essential elements plant pathway. In this study, calcineurin B-like protein-interacting kinase 26 (BdCIPK26) from Brachypodium distachyon was characterized. Overex...