نتایج جستجو برای: protein interaction map
تعداد نتایج: 1870650 فیلتر نتایج به سال:
Protein tyrosine phosphatase PTP-SL retains mitogen-activated protein (MAP) kinases in the cytoplasm in an inactive form by association through a kinase interaction motif (KIM) and tyrosine dephosphorylation. The related tyrosine phosphatases PTP-SL and STEP were phosphorylated by the cAMP-dependent protein kinase A (PKA). The PKA phosphorylation site on PTP-SL was identified as the Ser(231) re...
Protein complexes are key molecular machines executing a variety of essential cellular processes. Despite the availability of genome-wide protein-protein interaction studies, determining the connectivity between proteins within a complex remains a major challenge. Here we demonstrate a method that is able to predict the relationship of proteins within a stable protein complex. We employed a com...
To understand galaxies and their evolution, it is necessary to describe how the different scales interact: how the microscopic physics, such as star formation, or the large scale physics, such as galaxy interactions may modify the galaxy global shapes. The purpose of this review is to point out some general or recent topics related to such scale interactions, both observational and theoretical,...
Beta-arrestins (βarrs) critically mediate desensitization, endocytosis and signalling of G protein-coupled receptors (GPCRs), and they scaffold a large number of interaction partners. However, allosteric modulation of their scaffolding abilities and direct targeting of their interaction interfaces to modulate GPCR functions selectively have not been fully explored yet. Here we identified a seri...
High-throughput binary protein interaction mapping is continuing to extend our understanding of cellular function and disease mechanisms. However, we remain one or two orders of magnitude away from a complete interaction map for humans and other major model organisms. Completion will require screening at substantially larger scales with many complementary assays, requiring further efficiency ga...
Most cellular processes are enabled by cohorts of interacting proteins that form dynamic networks within the plant proteome. The study of these networks can provide insight into protein function and provide new avenues for research. This article informs the plant science community of the currently available sources of protein interaction data and discusses how they can be useful to researchers....
یکی از مسائلی که در سیستم sar مطرح می شود مسأله نویز speckle می باشد. منبع تولید نویز speckle فاز نسبی پراکنده گرهای مختلف در یک سلول رادار می باشد که نوسانات شدیدی در سیگنال دریافتی به وجود آورده و تصویر حاصل را دانه دانه می نماید. این نویز تفسیر تصاویر را مشکل و اطلاعات زیادی را مخفی می کند و لذا کاهش آن یکی از ملزومات در پردازش سیگنال sar است. الگوریتمهای متعددی جهت کاهش نویز speckle در نوا...
this study was carried out to evaluate the effects of different dietary protein (30, 35, 40%) and lipid levels (10, 12, 14%) on growth performance and physiological changes of juveniles caspian kutum (rutilus frisii kutum). six hundred and seventy five fish (1.15 ± 0.01 g) were distributed into 27 aquaria (45 l) and were fed four times daily for 8 weeks. interaction between protein and lipid di...
Protein molecular interaction fields are key determinants of protein functionality. PIPSA (Protein Interaction Property Similarity Analysis) is a procedure to compare and analyze protein molecular interaction fields, such as the electrostatic potential. PIPSA may assist in protein functional assignment, classification of proteins, the comparison of binding properties and the estimation of enzym...
Activation of the various mitogen-activated protein (MAP) kinase pathways converts many different extracellular stimuli into specific cellular responses by inducing the phosphorylation of particular groups of substrates. One important determinant for substrate specificity is likely to be the amino-acid sequence surrounding the phosphorylation site; however, these sites overlap significantly bet...
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