objective(s): the rotavirus nonstructural protein 4 (nsp4) is responsible for the increase in cytoplasmic calcium concentration through a phospholipase c-dependent and phospholipase c-independent pathways in infected cells. it is shown that increasing of intracellular calcium concentration in rotavirus infected cells is associated with the activation of some members of protein kinases family su...

in order to evaluation of genotype by environment interactions in holstein cows, iran was divided into cold, middle cold, temperate and hot climate regions. for this purpose used from 39570, 35813 and 18955 records for milk, fat and protein yields, respectively, to progeny test for 35 sires that have 50 daughters in each climate. the data were collected by the centre of breeding and improvement...

This paper presents the methods that have participated in SHREC 2022 contest on protein–ligand binding site recognition. The prediction of protein- ligand regions is an active research domain computational biophysics and structural biology plays a relevant role for molecular docking drug design. goal to assess effectiveness recognizing sites protein based its geometrical structure. Performances...

The sigma-2 (σ2) receptor was discovered nearly 40 years ago and recently identified as the Transmembrane Protein 97 (TMEM97, also known MAC30 (Meningioma-associated protein)). Aberrant σ2 activity has been linked to diseases conditions such schizophrenia, Alzheimer’s disease, neuropathic pain, traumatic brain injury, cancer. utility of a therapeutic target is currently under investigation in n...

Protein is a main component of our body. It is important to determine the reactivity of proteins in the medicine development. It is well-known that drugs go in hollows (so called “pocket”) of protein surfaces to react. We attempt to evaluate reactivity of proteins with the drugs. As a preliminary step, this paper presents a pocket shape evaluation technique. Supposing that the protein surfaces ...

As pathogens evolve effective schemes to overcome the effect of antibiotics, the prevalent "one drug and one drug target" approach is falling behind. We propose novel strategies for identifying potential multiple-drug targets in pathogenic protein-protein interaction (PPI) networks with the goal of disrupting known pathways/complexes. Given a set S of pathogenic pathways/complexes, we first con...