introduction: despite extensive studies about effects of crataegus monogyna on cardiovascular diseases yet, a few study has been undertaken antiarrhythmic property of this plant. aims of the present study were: 1) to determine the protective role of methanolic extract of c.monogyna on the rate-dependent model and the concealed conduction . 2) to explore the role of na+-k+ a tpase in the protect...

background & aim: homalium letestui pellegr (flacourtiaceae) used traditionally by the ibibios of southern nigeria to treat stomach ulcer, malaria and other inflammatory diseases was evaluated for antiulcer properties.  experimental: the effects of ethanol stem extract of h. letestui (200 – 600 mg/kg) and fractions (aqueous and dichloromethane, 400 mg/kg) on experimentally induced ulcer wer...

many herbaceous plants contain compounds that have biological effects in addition to their medicinal properties. they have compounds with numerous properties, including hypo lipidemic, hypoglycemic, antioxidant, and hepato protective ones, which have been analyzed at different levels. one of these plants, with the scientific name of berberis vulgaris, is barberry. the most important compounds i...

Edaravone, an antioxidant and radical scavenger, showed protective effects against oxidative stress-like condition. Paraquat (PQ) is a toxic herbicide considerable evidence suggests that oxidative stress and mitochondrial dysfunction contribute to PQ toxicity. In this study, protective effect of edaravone against PQ induced toxicity and reactive oxygen species (ROS) generation in A549 cells and...

Background: Hexachlorobutadiene (HCBD), a potent nephrotoxin can cause degeneration and necrosis in renal tubular epithelial cells in rodents. Its toxicity is due to conjugation with glutathione to form the related cysteine conjugate. This metabolite is then taken up by the kidney and cleared through renal tubular epithelial cells as a reactive thiol derivative by the enzyme β-lyase. Objective:...

Background: GTS, PTSM and ATSM are bis-thiosemicarbazone ligands used in the preparation of copper radiopharmaceuticals. Chemical structure of these materials indicates that they should have radio-protective effects.Objective: To study the radio-protective effects of GTS, PTSM and ATSM. Methods: This study has focused on radio-protective effects of these compounds at different doses (20, 40 and...

Objective(s): Resveratrol (RSV) is a naturally occurring plant polyphenol with cardioprotective, neuroprotective, immunoregulatory, and anticancer properties and is biologically effective against various diseases. This study aimed to investigate the chemopreventive effect of different doses of RSV against hepatocellular carcinoma (HCC) induced by  diethylnitrosamine (D...

Crocin, the main constituent of saffron (Crocus sativus L.), is a natural carotenoid which is known for its antioxidant activity. Liver as the organ that metabolizes many chemicals is one of the first position that is at risk of environmental pollutants. It is clear that compounds that exhibit antioxidant properties, scavenging of free radicals and inhibition of lipid peroxidation are expected ...