Prostate cancer is the most common noncutaneous cancer in males. Men of African origin are at a significantly higher risk as reflected in the higher incidence and mortality rates in this racial group. Metastases incidence increases parallel to serum levels of prostate-specific antigen (PSA), contributing significantly to morbidity and mortality. Staging of the disease involves bone scans, which...

BACKGROUND Finasteride was introduced to treat patients with benign prostatic hyperplasia (BPH) recently, and it has shown its effects in reduction of prostate volume and decrease of prostate-specific antigen (PSA). We want to know how and how much does finasteride affect prostate volume as well as PSA and prostate-specific antigen density (PSAD), since PSA and PSAD are widely used as screening...

Introduction Serum prostate-specific antigen (PSA) is of paramount importance as a diagnostic tool for the detection, staging, and monitoring of patients with prostate cancer. Because PSA is organ but not disease specific, it has certain limitations as a screening test for prostate cancer. After radical prostatectomy (RP), however, PSA is an excellent tumor marker with a high sensitivity and sp...

background: nowadays, highly specific aptamers generated by cell selex technology (systematic evolution of ligands by exponential enrichment) are being applied for early detection of cancer cells. prostate specific membrane antigen (psma), over expressed in prostate cancer, is a highly specific marker and therefore can be used for diagnosis of the prostate cancer cells. the aim of the present s...

PURPOSE To discuss the issue of screening for prostate cancer in elderly individuals. The impact of life expectancy on the choice of treatment in both patients and health care providers has been investigated as well. MATERIALS AND METHODS We identified studies published from 1990 onwards by searching the MEDLINE database of the National Library of Medicine. Initial search terms were "localize...

Owing to the fact that prostate cancer is the second cause of death behind lung cancer, several diagnostic strategies have been introduced in the past years. Among these prostate specific antigen is widely acknowledged to be the simplest and routine clinical parameter the purpose of this study is to reveal the contribution of the prostate specific antigen (PSA) in the diagnosis and tracking of ...

Background & Objective: As the prostate adenocarcinoma is one of the most common malignant tumors in males, looking for a marker to effectively predict aggressiveness and metastatic potential in an apparently localized cancer in initial needle biopsy specimens can help the clinicians to make more appropriate decision for treatment, planning, and choosing appropriate ta...

Prostate cancer represents the second highest malignancy rate in men all diagnoses worldwide. The development and progression of prostate is not completely understood yet at molecular level, but it has been reported that changes N-glycosylation prostate-specific antigen (PSA) occur during tumor genesis. In this paper we report on implementation a high-throughput capillary electrophoresis based ...

Cervical regional nodal involvement, as the first manifestation of prostatic cancer, has been rarely reported. Prostate cancer metastasis to the supraclavicular lymph nodes with negative immunohistochemical stain of PSA is even rarer. We report a case of prostate cancer with negative immunohistochemical stain of prostate-specific antigen presenting with left supraclavicular node enlargement. A ...

It is crucial to have early detection of prostate cancer as it the third most common in men and Prostate Specific Antigen (PSA) a protein-based biomarker commonly used achieve purpose. Besides, ISFET integrated with nanostructures such nanowire nanosphere has been focus research for disease diagnosis. Simulations are carried out Biosensor Lab investigate performance planar, structures detecting...