This paper proposes a new semi-automatic segmentation method for the prostate on 3D transrectal ultrasound images (TRUS) by combining the region and classification information. We use a random walk algorithm to express the region information efficiently and flexibly because it can avoid segmentation leakage and shrinking bias. We further use the decision tree as the classifier to distinguish th...

Loss of tissue organization is a hallmark of the early stages of cancer, and there is considerable interest in proteins that maintain normal tissue architecture. Prostate epithelial cells cultured in Matrigel form three-dimensional acini that mimic aspects of prostate gland development. The organization of these structures requires the tumor suppressor Dickkopf-3 (Dkk-3), a divergent member of ...

The ability to isolate prostate stem cells is essential to explore their role in prostate development and disease. In vitro prostate colony- and sphere-forming assays were used to quantitatively measure murine prostate stem/progenitor cell enrichment and self-renewal. Cell surface markers were screened for their ability to positively or negatively enrich for cells with enhanced growth potential...

The role of multiparametric MRI (mpMRI) in prostate cancer setting is increasingly consolidated and, as a result, its usage clinical practice exponential growth. However, beyond the gland, several key structures are included field view mpMRI scans. Consequently, various extra-prostatic incidental findings (IFs) belonging to different anatomical systems can be accidentally recognized. Therefore,...

The review article, based on the results of modern clinical and experimental studies, discusses general issues pathophysiology oxidative stress as a universal pathogenetic factor human diseases particular pathophysiological aspects example chronic bacterial prostatitis. Separately, most studied mechanisms in pathogenesis infectious inflammatory process associated with prostatitis are highlighte...

In dogs, the most frequent diseases of prostate gland are benign hyperplasia (BPH), acute and chronic prostatitis, squamous metaplasia, tumors. New diagnostic tools comprise markers in blood urine, as well advanced imaging methods. The therapy can be initialized with 5α-reductase-inhibitor finasteride or an anti-androgenic compound, prolonged a long-acting gonadotropin-releasing-hormone (GnRH)-...