UNLABELLED Backround: Surgical operations are alternative treatments in persons with Obstructive Sleep Apnea Syndrome who cannot tolerate continuous positive airway pressure therapy. Drug-Induced Sleep Endoscopy is a method with which somnolence is pharmacologically induced and collapse is evaluated through nasal endoscopy in patients with Obstructive Sleep Apnea Syndrome. AIMS We aimed to ev...

BACKGROUND The combination of propofol-remifentanil for procedural deep sedation in spontaneously breathing patients is characterized by the frequent incidence of side effects, especially respiratory depression. These side effects may be due to either the drug combination or the drug delivery technique. Target-controlled infusion (TCI) might optimize drug delivery. In this prospective, randomiz...

Preoperative acute hypervolemic hemodilution (AHHD) is a technique used in anesthesia to reduce the number of blood cells lost during intraoperative bleeding. The aim of the present study was to evaluate the effect of the hypervolemic hemodilution of 6% hydroxyethyl starch 130/0.4 on the EC50 of propofol at two clinical endpoints. A total of 20 patients undergoing AHHD following epidural anesth...

PURPOSE Cardiopulmonary bypass is known to alter propofol pharmacokinetics in patients undergoing cardiac surgery. However, few studies have evaluated the impact of these alterations on postoperative pharmacodynamics. This study was designed to test the hypothesis that changes in propofol pharmacokinetics increase hypnotic effects after cardiopulmonary bypass. METHODS Twenty patients schedule...

STUDY OBJECTIVE To investigate the effects of preanesthetic oral clonidine on total propofol requirement for uniform minor surgery (breast conservative surgery: breast cancer removal with axillary lymph node dissection), and to compare the action of clonidine with that of preanesthetic oral diazepam, a commonly used benzodiazepine. DESIGN Randomized double-blinded study. SETTING Operating r...

Penehyclidine hydrochloride (PH), a new anticholinerigic drug associated with few cardiovascular side effects, was used widely as premedication in China. There is no information on the pharmacodynamic interaction between PH and anesthetics for loss of consciousness (LOC). This study was designed to determine the effects of premedicated PH on the propofol dose requirement for LOC and Bispectral ...

We have had this study to evaluate the clinical profile of target-controlled infusion-based anesthesia using remifentanil and propofol. 116 ASA I-II patients undergoing elective laparoscopic cholecystectomy (LCH) were enrolled. TCI Remifentanil was set at 8 micrograms. L - 1 as target and TCI propofol at 4 mcg/ml throughout the whole procedure. The hemodynamics during induction of anesthesia an...

Intelisano T.R., Kitahara F.R., Otsuki D.A., Fantoni D.T., Auler Jr J.O.C. & Cortopassi S.R.G. 2008. Total intravenous anaesthesia with propofol-racemic ketamine and propofol-S-ketamine: A comparative study and haemodynamic evaluation in dogs undergoing ovariohysterectomy. Pesquisa Veterinária Brasileira 28(4):216-222. Departamento de Cirurgia, Faculdade de Medicina Veterinária e Zootecnia, Uni...

BACKGROUND Pre-medication with clonidine reduces the requirement for volatile agents during general anaesthesia. This may also be true for anaesthesia with propofol, but the amount of dose reduction has not been measured. Because clonidine also affects cardiac output and thus regional blood flow it could alter the pharmacokinetics of propofol. This randomized, double-blind placebo-controlled tr...

When recovering from general anesthesia, upon removal of the endotracheal tube, patients may experience a high dynamic response in the circulatory system, along with choking and restlessness. This study was designed to study the effect of maintaining an intravenous infusion of remifentanil or propofol on the performance of general anesthesia, including on the cardiovascular response, choking an...