objective(s): this study investigated the protective effect of tanshinone iia sodium sulfonate (tss) on ischemia-reperfusion (i/r) induced cardiac injury, and the underlying mechanism of action. materials and methods:male sprague-dawley rats were subjected to a 30-min coronary arterial occlusion followed by 24 hours' reperfusion. half an hour before the left coronary artery ligation, rats ...

this paper aims to study the role of women in agricultural promotion and its effect on rural development. research method in this study was based on a survey and the required information was collected through questionnaire from a sample of women especially rural women. the data were analyzed using logit model. the results showed that women had a major role in farming including producion, conser...

Mitochondria play important roles in regulating cell bioenergetics status and reactive oxygen species (ROS) generation. ROS-induced mitochondrial damage is among the main intracellular signal inducers of autophagy. Autophagy a cellular catabolic process that regulates protein organelle turnover, while selective form autophagy, mitophagy, specifically targets dysfunctional degradation. This stud...

financial literacy of investors reduces uncertainty on future decisions and increases predictability of investment policies in financial markets. thus, the lack of clear information on financial markets is a determining factor in the arrival of domestic and foreign capitals and their quick exit in case of crisis. the lack of transparency and basic knowledge on decisions and failure to provide r...

although in mexico the cases and the experiences in bioenergy production are limited, at a worldwide level the knowledge in this area has grown up significantly. for example, unlike argentina and brazil, mexico has only recently begun its bioenergy production from agricultural crops. so this paper will present a review of the actual conditions encountered in mexico as far as biofuels production...

BACKGROUND We previously reported the anti-estrogenic activity of the brown seaweed, Fucus vesiculosus. The present study aimed to further investigate its anti-estrogenic modes of action and to assess other potentially biologically relevant anti-tumorigenic effects in estrogen receptor (ER)-dependent and -independent female cancer cell lines. METHODS The CALUX® assay was used to determine the...

Autophagy-related protein ATG5-ATG12 is an essential complex for the autophagophore elongation in autophagy, which has been reported to be involved in foot-and-mouth disease virus (FMDV) replication. Previous reports show that ATG5-ATG12 positively or negatively regulates type I interferon (IFN-α/β) pathway during virus infection. In this study, we found that FMDV infection rapidly induced LC3 ...

Abstract Introduction The circadian rhythm plays a critical role in many biological processes. Recently, autophagy was suggested as regulating factor of by reducing protein trafficking. Cereblon (CRBN) is component the E3 ubiquitin ligase complex for ubiquitination and degradation target proteins. Interestingly, cereblon ubiquitinates beclin 1, potent inducer. Accordingly, changes are likely to...

Objective: Autophagy is highly active in ovariectomized mice experiencing hormone deprivation, especially the uterine mesenchyme. responsible for turnover of vasoactive factors uterus, which was demonstrated anti-Müllerian receptor type 2 (<i>Amhr2</i>)-Cre-driven autophagy-related gene 7 (<i>Atg7</i>) knockout (<i>Amhr-Cre/Atg7<sup>f/f</sup></i> ...