نتایج جستجو برای: proguanil
تعداد نتایج: 315 فیلتر نتایج به سال:
I read with interest the recent analysis by Eick-Cost and others, which examined associations among U.S. military personnel between various neurologic and psychiatric diagnoses and earlier use of mefloquine. Although not accounting formultiple hypothesis testing, the authors’ finding in subgroup analysis of a significantly increased risk of posttraumatic stress disorder (PTSD) with use of meflo...
The widespread introduction of artemisinin-based combination therapy has contributed to recent reductions in malaria mortality. Combination therapies have a range of advantages, including synergism, toxicity reduction, and delaying the onset of resistance acquisition. Unfortunately, antimalarial combination therapy is limited by the depleting repertoire of effective drugs with distinct target p...
Malaria eradication necessitates new tools to fight the evolving and complex Plasmodium pathogens. These tools include prophylactic drugs that eliminate Plasmodium liver stages and consequently prevent clinical disease, decrease transmission, and reduce the propensity for resistance development. Currently, the identification of these drugs relies on in vitro P. falciparum liver stage assays or ...
Cycloguanil pamoate is an antimalarial drug recently developed by Thompson et al. (1963) in the United States. It is closely allied to the existing drugs, proguanil and pyrimethamine, and when administered intramuscularly is slowly released and thus maintains an effective antiplasmodial blood level for a prolonged period. The advantages offered by a repository drug become obvious when considera...
OBJECTIVE To describe the clinical features and management of African migrants recently arrived in Western Australia and subsequently diagnosed with malaria. DESIGN, PARTICIPANTS AND SETTING Retrospective case record analysis of African migrants aged > or = 16 years with malaria referred to Royal Perth Hospital (RPH) from the WA Migrant Health Unit (MHU) between 1 March 2003 and 30 September ...
The management of malaria has become a problem of increasing importance in the world, and particularly in Africa. There are three main facets available for the management and control of malaria, namely, intervention measures, treatment of the disease, and prevention against the disease. In Africa, all measures taken against malaria must be affordable and accessible. Due to low economic capacity...
BACKGROUND Critical to the development of new drugs for treatment of malaria is the capacity to safely evaluate their activity in human subjects. The approach that has been most commonly used is testing in subjects with natural malaria infection, a methodology that may expose symptomatic subjects to the risk of ineffective treatment. Here we describe the development and pilot testing of a syste...
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