Background: Dermatoglyphics are the dermal ridge configurations on the digits, palms and soles. Dermatoglyphic polymorphism results from the co-operation of genetic and environmental factors. The Dermatoglyphic analysis is a valuable completion of initial diagnosis of some syndromes genetically determined. Our objective was to assess dermatoglyphics study results against standard chromosomal an...

A 50 years old male patient to referred to our clinic for multiple hard diffused lesions on palms, plantars and penis. The Genesis of the problem goes back to 10 years earlier. The lesions appeared first on the soles and gradually new lesions appeared on the palms and eventually on the penis, so that stretching and contraction of the fingers and toes has become painful. During the last 6 years,...

Further expanding the major findings of the landmark study by Harrison and colleagues showing that late-life pharmacological inhibition of the enzyme mammalian Target Of Rapamycin (mTOR) –a conserved integrator of nutrient and growth factor signaling-is sufficient to significantly extend lifespan in mice on rapamycin feeding [1], Selman and colleagues have recently revealed that loss of the rib...

Spartan (also known as DVC1 and C1orf124) is a PCNA-interacting protein implicated in translesion synthesis, a DNA damage tolerance process that allows the DNA replication machinery to replicate past nucleotide lesions. However, the physiological relevance of Spartan has not been established. Here we report that Spartan insufficiency in mice causes chromosomal instability, cellular senescence a...

conclusions subcutaneous nodules in the absence of a local reaction at the site of bcg vaccination may be the sole manifestation of disseminated bcg disease. case presentation we report on an 11-months-old boy with prolonged fever and diffuse hyperpigmented subcutaneous nodules. due to lymphopenia, oral thrush and severe adverse reaction to bcg vaccination, the possibility of primary immunodefi...

background: myelodysplastic syndrome is a mixed clonal disorder of bone marrow progenitor cells. understanding the pattern of the different lineage-specific, immature, and mature markers in myelodysplastic syndrome will help in setting-up the frame of reference to diagnose. patients and methods: we compared 60 bone marrow samples from 30 newly-diagnosed patients with myelodysplastic syndrome an...

conclusions as green tea is an essential source of antioxidants such as flavonoids, suppression of reactive oxygen species (ros) generation may be in part considered as the neuroprotective mechanism on acr induced neurotoxicity. background acrylamide (acr) monomer is an effective neurotoxicant, which damages the central and peripheral nervous systems in humans and animals. green tea, an infusio...