نتایج جستجو برای: progeroid syndrome
تعداد نتایج: 622026 فیلتر نتایج به سال:
Werner syndrome (WS) is a rare inheritable progeroid syndrome caused by a mutation in the WRN gene. Although WS has been described as a characteristic appearance of very slender extremities with a stocky trunk, few studies have investigated the loss of muscle mass, fat mass distribution (body composition), and mobility according to age and sex. Therefore, the aim of this study was to precisely ...
How congenital defects causing genome instability can result in the pleiotropic symptoms reminiscent of aging but in a segmental and accelerated fashion remains largely unknown. Most segmental progerias are associated with accelerated fibroblast senescence, suggesting that cellular senescence is a likely contributing mechanism. Contrary to expectations, neither accelerated senescence nor acute ...
هدف: در این مطالعه به بررسی اثر تزریق کورتیکواسترویید در درمان infrapatellar fat pad syndrome در بیماران مراجعه کننده به درمانگاه ارتوپدی بیمارستان امیرالمومنین (ع) تهران در سال 1388 پرداختیم.روش مطالعه: این مطالعه به صورت یک بررسی مداخله ای (interventional) از نوع نیمه تجربی (quasi-experimental) انجام گردیده است. جامعه مورد بررسی شامل 60 نفر از افراد مبتلا به infrapatellar fat pad syndrome بود...
Hutchinson-Gilford progeria syndrome (HGPS) is a segmental progeroid syndrome with multiple features suggestive of premature accelerated aging. Accumulation of progerin is thought to underlie the pathophysiology of HGPS. However, despite ubiquitous expression of lamin A in all differentiated cells, the HGPS mutation results in organ-specific defects. For example, bone and skin are strongly affe...
Werner syndrome (WS) is a rare autosomal progeroid disorder caused by a mutation in the gene encoding the WRN (Werner syndrome protein), a member of the RecQ family of helicases with a role in maintaining genomic stability. Genetic association studies have previously suggested a link between WRN and susceptibility to benzene-induced hematotoxicity. To further explore the role of WRN in benzene-...
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