PURPOSE Prostate Cancer (PCa) is one of the most common cancers in men and its early detection can provide a high chance of cure. The detection of Vitamin D Receptor (VDR) gene polymorphisms may be useful as a molecular indicator of clinical outcome, once VDR is implicated in a wide variety of biological processes including modulation of the immune response and inhibition of cancer cell growth,...

drought stress is one of the most important dangers for increasing the yield and good production of crops in iran and the world. to evaluate the genetic diversity of rapeseed genotypes, identifying the drought resistance indices and drought tolerant genotypes, 16 genotypes were tested in a randomized complete block design (rcbd) with three replications and two different water regimes (irrigated...

background and objective: prostate cancer is a prevalent disease around the world. the prostatic specific antigen (psa) test has recently proved itself as a useful method for the diagnosis and examination of patients with prostatic cancer. the objective of this study was to compare the stability of free psa and total psa in different storage settings. materials and methods: samples were obtaine...

PSA is a 33-KDa serine protease that is produced predominantly by prostate epithelium. However, it has been shown that about 30-40% of female breast tumors produce PSA and its production is associated with the presence of estrogen and progesterone receptors. We have now developed a new tissue culture system to study PSA production in breast cancer and its association with prognostic factors...

background: breast cancer is the most common cancer in women. prostate‑specifc antigen  (psa) is a marker of prostate gland malignancy, which has been considered in cases with breast cancer in recent years. the goal of this study was to determine total and free psa levels in cases with malignant and benign breast lesions. methods:   in  this case–control study, ninety women with histological pr...

background: stereotactic body radiotherapy (sbrt) has emerged as an effective treatment for localized prostate cancer. however, prostate-specific antigen (psa) kinetics after sbrt has not been well characterized. the objective of the current study is to analyze the rate of psa decline and psa nadir following hypofractonated sbrt in localized prostate cancer. materials and methods: from 2008 to ...

There are emerging data on novel tumor markers such as matrix metalloproteinase-2 (MMP-2 or gelatinase-A), which play a key role in tissue invasion and metastasis. We designed an investigation to assess the usefulness of MMP-2 activity as compared to prostate specific antigen (PSA) in cancer staging process. We have analyzed the circulating form of MMP-2 in serum samples of patients suffering f...

background: prostate specific antigen (psa) is a protein currently used in vconjunction with the digital rectal examination to detect and guide management of prostate cancer. there are several causes of increase in serum psa including urological manipulations, medications, prostatic diseases, prostate cancer, prostate inflammation or infection, etc. some studies had reported cystoscopy to cause...

Resistance to apoptosis is a critical feature of neoplastic cells. Galectin-1 is an endogenous carbohydrate-binding protein that induces death of leukemia and lymphoma cells, breast cancer cells, and the LNCaP prostate cancer cell line, but not other prostate cancer cell lines. To understand the mechanism of galectin-1 sensitivity of LNCaP cells compared with other prostate cancer cells, we cha...