Pheromone-binding proteins (PBP) supply olfactory neuron cells with pheromones by binding the ligands they are tailored for and carrying them to their receptor. The function of a PBP as an efficient carrier requires fast ligand uptake and release. The molecular basis of the ligand-binding mechanism was addressed here for the intriguing case of the PBP of the silk moth Bombyx mori. This PBP comp...

The presence of an additional penicillin-binding protein (PBP) was demonstrated in methicillin-resistant strains of Staphylococcus epidermidis, S. haemolyticus, S. hominis, and S. simulans. In these four species, the apparent molecular mass of this protein was analogous to that of PBP 2' of methicillin-resistant S. aureus SR 1550-9. It exhibited a low affinity for methicillin, cephalothin, and ...

Penicillin binding protein-1A (PBP-1A; IPR011816) plays a pivotal role in the biogenesis of cell-wall and biosynthesis of peptidoglycan in bacteria. It is considered to be a novel target for pneumonia. The present study is to deduce the structure of the PBP-1A using ICM Molsoft and to validate the same with Ramachandran plot. These bioinformatics tools have been used to identify a lead molecule...

Group B streptococci (GBS; Streptococcus agalactiae) are the leading cause of neonatal invasive diseases and are also important pathogens for adults. Penicillins are the drugs of first choice for the treatment of GBS infections, since GBS have been regarded to be uniformly susceptible to penicillins so far. Here we characterize the first strains of GBS with reduced penicillin susceptibility (PR...

Nowadays the new product and its importance are consideredas an essential strategy for staying in business. Though the hi-techindustry has focused on value innovation and improving the qualityof the new product development (NPD) process to drive new productperformance, new product success has not changed dramaticallyover the years. This study presents a novel approach based on structuralequatio...

Introduction: Pigeon Breeder’s Pneumonitis (PBP) results due to a complex pathophysiology that includes exposure avian antigens. Susceptibility has been linked human leukocyte antigen (HLA) class II, though consensus not reached. The goal of this systematic review is further elucidate the association between PBP and HLA-DR subtypes.

Hydroponic lettuce is one type of plant that widely developed today by farmers to be used as a farm for the community, especially millennials. Hydroponics way farming again up date in midst current Covid-19 pandemic because it not difficult cultivate and can provide benefits farmers. The purpose research was determine feasibility hydroponic during pandemic. conducted Kolaka Regency with populat...

The purpose of this study was to evaluate the economic feasibility producing copper oxide (CuO) nanoparticles using green synthesis method on an industrial scale for 10 years by evaluating from engineering and perspective. Various parameters are used analyze viability, including Gross Profit Margin (GPM), Cumulative Net Present Value (CNPV), Payback Period (PBP), as well variations in sales, ta...