In this paper, we describe how to construct physical computer network topologies which can support the establishment of overlays that reduce or increase the distances between nodes. Reducing pairwise distances (i.e., compression) implies that the overlay enjoys significantly lower inter-node latencies compared to the ambient physical network; such an overlay can be used to implement a “high-per...

Animal research is a vital component of US research and well-functioning animal research facilities are critical both to the research itself and to the housing and feeding of the animals. The Office of Animal Care (OAC) at Seattle Children's Hospital Research Institute realized it had to improve the efficiency and safety of its animal research facility (ARF) to prepare for expansion and to adva...

In recent years, technologically advanced high-throughput techniques have been developed that replace, reduce or refine animal use in vaccine quality control tests. Following validation, these tests are slowly being accepted for use by international regulatory authorities. Because regulatory acceptance itself has not guaranteed that approved humane methods are adopted by manufacturers, various ...

The present paper describes the methods for producing egg yolk antibodies against Bordetella bronchiseptica. In comparative experiments, avian and mammalian antibodies were applicated in diagnostic test systems. The results of these investigations show the possibility of substituting mammalian antibodies for IgY in enzyme immunoassay and indirect immunofluorescence.

Mycobacterium pseudoshottsii is a fish pathogen that produces mycolactone. Here, we report the complete chromosome sequence of a type strain of M. pseudoshottsii (JCM 15466). The sequence will represent essential data for future phylogenetic and comparative genome studies of mycolactone-producing mycobacteria.

The DNA sequences of two IncHI2 plasmids, pEC-IMP and pEC-IMPQ, from metallo-beta-lactamase-producing Enterobacter cloacae clinical isolates were determined. The two conjugative plasmids are almost identical, but pEC-IMPQ carries an additional segment containing an orf513 (ISCR1), a truncated 3' conserved sequence, and a qnrB2. Comparative analyses provide support for the proposed ISCR1-mediate...

We review various normal form representations of Boolean functions and outline a comparative study between them, which shows that the median normal form system provides representations that are more efficient than the classical DNF, CNF and Reed–Muller (polynomial) normal form representations. We present an algorithm for producing median normal form representations of Boolean functions.

Mycobacterium ulcerans subsp. shinshuense produces mycolactone and causes Buruli ulcer. Here, we report the complete sequence of its genome, which comprises a 5.9-Mb chromosome and a 166-kb plasmid (pShT-P). The sequence will represent the essential data for future phylogenetic and comparative genome studies of mycolactone-producing mycobacteria.

Past research revealed issues with artificial event data used for comparative analysis of process mining algorithms. The aim of this research is to design, implement and validate a framework for producing artificial event logs which should increase discriminatory power of artificial event logs when evaluating process discovery techniques.