The forming limit diagram (FLD) is probably the most common representation of sheet metal formability and can be defined as the locus of the principal planar strains where failure is most likely to occur. Low carbon steel sheets have many applications in industries, especially in automotive parts, therefore it is necessary to study the formability of these steel sheets. In this paper, FLDs, wer...

In this paper an algorithm for large strain elasto-plasticity with isotropic hyperelasticity based on the multiplicative decomposition is formulated. The algorithm includes a (possible) constitutive equation for the plastic spin and mixed hardening in which the principal stress and principal backstress directions are not necessarily preserved. It is shown that if the principal trial stress dire...

A constitutive model based on two–dimensional unstructured Galerkin finite volume method (GFVM) is introduced and applied for analyzing nonlinear behavior of cracked concrete structures in equilibrium condition. The developed iterative solver treats concrete as an orthotropic nonlinear material and considers the softening and hardening behavior of concrete under compression and tension by using...

Animal models are invaluable tools which allow us to investigate the microbiome-host dialogue. However, experimental design introduces biases in the data that we collect, also potentially leading to biased conclusions. With obesity at pandemic levels animal models of this disease have been developed; we investigated the role of experimental design on one such rodent model. We used 454 pyroseque...

The impact of 4-epi-oxytetracycline (4-EOTC), one of the main oxytetracycline (OTC) metabolites, on the gut microbiota and physiological metabolism of Wistar rats was analyzed to explore the dynamic alterations apparent after repeated oral exposure (0.5, 5.0 or 50.0 mg/kg bw) for 15 days as shown by 16S rRNA pyrosequencing and UPLC-Q-TOF/MS analysis. Both principal component analysis and cluste...

A number of quantitative trait loci (QTLs) for postnatal growth have previously been reported in mice. As effects of the QTLs are usually small and similar to one another in magnitude, it is generally difficult to know which loci are major contributors to postnatal growth. We applied principal component analysis to a genome-wide search for QTLs affecting postnatal growth in body weight weekly r...

Functional genetic analyses in mice rely on efficient and in-depth characterization of the behavioral spectrum. Automated home-cage observation can provide a systematic and efficient screening method to detect unexplored, novel behavioral phenotypes. Here, we analyzed high-throughput automated home-cage data using existing and novel concepts, to detect a plethora of genetic differences in spont...