Abstract Aims Blood loss from the gastrointestinal tract is most common cause of iron deficiency anaemia (IDA) in adult men and post-menopausal women. Up to 10% patients with IDA have underlying cancer. The aim this study was investigate prevalence oesophago-gastric Methods A retrospective cohort all newly diagnosed cancers (adenocarcinoma squamous cell carcinoma) high grade dysplasia discussed...

We report a case of mixed adenoneuroendocrine carcinoma (MANEC) of stomach with tubular adenoma and well-differentiated neuroendocrine tumor (WD-NET) in the primary tumor in the stomach giving rise to biphenotypic regional nodal metastases. A 35-year-old woman with abdominal pain was found to have a 1.8-cm gastric lesion, diagnosed as WD-NET (intermediate grade) on the biopsy. The resection spe...

Gastritis represents an inflammation of the stomach lining in response to injury. It is either acute or chronic, and has many underlying causes which can be diagnosed and classified histologically where endoscopic appearances such as redness are often misleading. Gastritis is seldom if ever symptomatic, but usually have important clinical sequelae, principally duodenal and gastric ulceration, g...

Aim: The histologic features, potential behavior, genetic pathways, epidemiological characteristics and response to treatment of gastric carcinomas, is showing heterogeneity. Cytokeratin (CK), an intermediate-sized filament detected primarily in epithelial cells. Most commonly used CKs in immunohistochemical studies are CK7, CK20 and these molecules are used as a markers to help identify the si...

NF-κB pathway is a link between inflammation and cancer and is involved in cellular responses to different stimuli. Gastrointestinal lumen is exposed to many inflammatory agents such as foods, free radicals and bacterial or viral antigens. The aim of the present study was to evaluate the possible role of NF-κB1in gastric adenocarcinoma. To detect the relative level of NF-κB1transcript, total RN...

Animal studies showed that male gastric tissues respond more rapidly to Helicobacter pylori (H.pylori) infection but the possible mechanisms remained unclear. There is no data about gender specific activity of Androgen receptor (AR) as an independent unfavorable prognostic factor in gastric cancer and its interactions with H.pylori and angiogenesis in both genders. To compare the pathogenesis o...

Metastasis of gastroesphageal junction (GEJ) adenocarcinoma in skeletal muscle is rare and primary sites for skeletal muscle metastases are usually lung, renal and colorectal cancer. We have encountered with the first case report of solitary psoas muscle metastasis of GEJ adenocarcinoma. Here we describe a 65 years old man was diagnosed with GEJ adenocarcinoma in tertiary hospital, Tehran, Iran...