Rationale and Objectives: Hemoglobinopathies are among the most commonly inherited genetic disorders in humans considered as a major public health problem Saudi Arabia. The prevalence of hemoglobinopathies is severe threat to society future generations if assessment pre-marriage cohorts not monitored. purpose this study analyze type relation age, gender mutations assess cohort. Materials Method...

Mục tiêu nghiên cứu: Mô tả đặc điểm huyết học và tỷ lệ lưu hành gen bệnh tan máu bẩm sinh (thalassemia) ở trẻ em 3-15 tuổi tại huyện Hà Quảng, tỉnh Cao Bằng. Phương pháp cắt ngang có phân tích trên đối tượng là 223 từ 3 -15 Bằng tháng 9/2021 đến 1/2023. Kết quả Tỷ thiếu chung 18,9%; mức độ nặng 0,9%, vừa 5,8%, nhẹ 12,1%; hồng cầu nhỏ nhược sắc 25,6%; sắt đơn thuần 1,8%; 0,4%, bất thường tố 7,2%...

Oxidative damage induced by free globin chains has been implicated in the pathogenesis of the membrane abnormalities observed in alpha and beta thalassemia. We have evaluated transport of Na+ and K+ in erythrocytes of patients with thalassemias as well as in two experimental models that use normal human red blood cells, one for alpha thalassemia (methylhydrazine treatment, alpha thalassemia lik...

background: falling has a great importance among the elderlies. even if no physical injury occurs, it can cause fear of fallingdown again and, consequently, reduce older adults’ activities. with regard to the prevalence of falling among older adults, its prevention is essential. therefore, the present study was aimed to define the effect of need-based education on prevention of older adults’ fa...

background: heart disease is the main cause of mortality and morbidity in patients with beta thalassemia, rendering its early diagnosis vital. we studied and compared echocardiographic findings in patients with beta thalassemia major, patients with beta thalassemia intermedia, and a control group. methods: eighty asymptomatic patients with thalassemia major and 22 asymptomatic cases with thalas...

Thalassemia is the most common inherited single gene blood disease worldwide and present a significant health problem in world. Approximately, 1.5% of global populations (An estimated 80–90 million people) are carriers β-thalassemia. Around 5% Indonesia population thought to carry thalassemia gene. The globin imbalance β-thalassemia major causes hemolysis ineffective erythropoiesis which result...

Hemoglobin E (HbE) is an extremely common structural hemoglobin variant that occurs at high frequencies throughout many Asian countries. It is a β-hemoglobin variant, which is produced at a slightly reduced rate and hence has the phenotype of a mild form of β thalassemia. Its interactions with different forms of α thalassemia result in a wide variety of clinical disorders, whereas its coinherit...

Advances in treatment of thalassemia have led to the aging of thalassemic patients, and consequently concern about successful reproductive outcome is augmented. Although women with thalassemia intermedia only were considered competent of achieving pregnancy, case series reveal the willingness of both thalassemia major and thalassemia intermedia women to have a family. Pregnancy in general is ch...

Thalassemia is a genetic disorder that involves abnormal haemoglobin formation. The two main categories of thalassemia are alpha and beta thalassemia that are then divided into further subcategories. While some mild forms of thalassemia might even go unnoticed and only cause mild anaemia and iron deficiency problems in patients, other more severe forms of thalassemia can even result in death. I...

background: general health is related not only to physical illness but also to mental and social conditions including personality traits and the quality of life. the main objective of the current study was to investigate the relationship between five main personality factors, quality of life, and mental health in patients suffering from thalassemia. materials and methods: the current study was ...