In the 40 years since the inception of dynamic NMR methods, much effort has been invested to quantify and understand the barrier to rotation about the C-N bond in amides.1 Carbamates, which also exhibit the approximately planar N-CdO framework responsible for hindered rotation in amides, have received considerably less attention, although they are important biologically as anticonvulsants, loca...

Zn/AcOH on silica gel converts a range of structurally different sulfoxides to their corresponding thioethers in excellent yields under microwave irradiation. It has been found that chemoselective deoxygenation of sufoxides can be achieved in the presence of other reducible functional groups such as acetals, acids, amides,   esters, ketones and nitriles.  

The first highly accelerated Niementowski reaction of anhranilic acid with some amides or ketones under microwave irradiation leading to quinazolinones and quinoline derivatives is described. These reactions represent some examples of efficient microwave irradiation promoted organic condensation in which the reactions can be carried out in open vessels and provides products of high purity w...

Transition metal‐free Claisen‐type condensation between two different amides was developed. N ‐phenyl‐ ‐tosylbenzamide derivatives reacted with enolizable such as ‐methyl pyrrolidinone and , ‐dimethyl acetamide in the presence of NaHMDS to give their corresponding β ‐ketoamides moderate‐to‐good yields.

Amide hydrogen exchange (HX) is widely used in protein biophysics even though our ignorance about the HX mechanism makes data interpretation imprecise. Notably, the open exchange-competent conformational state has not been identified. Based on analysis of an ultralong molecular dynamics trajectory of the protein BPTI, we propose that the open (O) states for amides that exchange by subglobal flu...

1-Azabicyclo [1.1.0] butane (ABB) bearing the highly strained bicyclic structure, which is synthetically useful for the preparation of 3-substituted azetidines, was obtained by the cyclization of 2,3-dibromopropylamine hydrobromide derived from inexpensive allylamine only with organolithium compounds and lithium amides. When other bases were employed, such as potassium, sodium, and magnesium sp...

This communication describes the chemoselective metal-free reduction of tertiary amides to the corresponding amines. Hantzsch ester is used as a mild reducing agent for the reduction of trifluoromethanesulfonic anhydride activated amides providing the tertiary amines with high functional group tolerance.

The preparation of peptide thioesters using Fmoc chemistry requires their synthesis as amides flowed by an N -> S-acyl shift reaction. Recently, bis(2-sulfanylethyl)amino-trityl-polystyrene (SEA) resin has been reported (1, 2), where the peptide is synthesized as a secondary amide, and the N -> S-acyl shift occurs by reaction of one of the two 2-sulfanylethyl groups. The PAET resin described he...