نتایج جستجو برای: prediabetic state

تعداد نتایج: 858354  

Journal: :The journals of gerontology. Series A, Biological sciences and medical sciences 2012
O G Geirsdottir A Arnarson K Briem A Ramel P V Jonsson I Thorsdottir

BACKGROUND Insulin is a stimulator of skeletal muscle protein anabolism and insulin resistance might therefore negatively affect muscle protein metabolism. We investigated muscle mass and physical function before and after a resistance exercise program in participants with prediabetes or type 2 diabetes mellitus (T2DM) in comparison to healthy controls. METHODS This was a secondary analysis o...

2006
Matthew P. Burnham Ian T. Johnson Arthur H. Weston

Burnham, Matthew P., Ian T. Johnson, and Arthur H. Weston. Reduced Ca -dependent activation of large-conductance Ca -activated K channels from arteries of Type 2 diabetic Zucker diabetic fatty rats. Am J Physiol Heart Circ Physiol 290: H1520–H1527, 2006. First published November 4, 2005; doi:10.1152/ajpheart.00827.2005.—Although it is well established that diabetes impairs endotheliumdependent ...

2011
Eitan M. Akirav Maria-Teresa Baquero Lynn W. Opare-Addo Michael Akirav Eva Galvan Jake A. Kushner David L. Rimm Kevan C. Herold

OBJECTIVE β-Cell and islet endothelial cell destruction occurs during the progression of type 1 diabetes, but, paradoxically, β-cell proliferation is increased during this period. Altered glucose tolerance may affect β-cell mass and its association with endothelial cells. Our objective was to study the effects of glucose and inflammation on islet vascularity and on β function, mass, and insulin...

Journal: :Journal of diabetes mellitus 2012
Lu-Te Chuang Robert H Glew Chia-Chun Li Dorothy J VanderJagt Julie S Broyles Gretchen M Ray Vallabh O Shah

OBJECTIVE Although abnormalities in the fatty acid composition of serum and red cell membrane phospholipids of patients with type 2 diabetes are well-documented, lacking are studies of this issue in prediabetic individuals. MATERIALS/METHODS For this cross-sectional study, we recruited 180 subjects (30-80 years), 56 of whom were normal with regard to glucose control (HbA1c, <5.7%), 61 who had...

2010
Anke Tönjes Mathias Fasshauer Jürgen Kratzsch Michael Stumvoll Matthias Blüher

AIM Altered adipokine serum concentrations early reflect impaired adipose tissue function in obese patients with type 2 diabetes (T2D). It is not entirely clear whether these adipokine alterations are already present in prediabetic states and so far there is no comprehensive adipokine panel available. Therefore, the aim of this study was to assess distinct adipokine profiles in patients with no...

2017
Ji Eun Jun Seung-Eun Lee You-Bin Lee Jae Hwan Jee Ji Cheol Bae Sang-Man Jin Kyu Yeon Hur Moon-Kyu Lee Jae Hyeon Kim

AIM Serum albumin concentration is associated with both type 2 diabetes and metabolic syndrome (MetS). We sought to investigate whether baseline serum albumin and change in serum albumin could be independent risk factors for prediabetes in subjects without MetS. We further examined the effect of serum albumin on progression to overt diabetes in subjects who developed prediabetes. METHODS Amon...

Journal: :Journal of Immunology 2023

Abstract It is unknown whether dysregulated CSF1R himonocytes/macrophages drive the progression to diabetes and if their removal endogenous replacement with fresh macrophages resolves disease. Therefore, we hypothesize that depletion of activated CSF1R+ tissue using a monoclonal antibody against freshly differentiated will alleviate inflammation in tissues ameliorate diabetes-associated disease...

Journal: :American journal of physiology. Heart and circulatory physiology 2006
Matthew P Burnham Ian T Johnson Arthur H Weston

Although it is well established that diabetes impairs endothelium-dependent vasodilation, including those pathways involving vascular myocyte large-conductance Ca(2+)-activated K(+) channels (BK(Ca)), little is known about the effects of diabetes on BK(Ca) activation as an intrinsic response to contractile stimulation. We have investigated this mechanism in a model of Type 2 diabetes, the male ...

2010
Melanie A. Ruffner Paul D. Robbins

BACKGROUND We and others have previously demonstrated that treatment with bone marrow derived DC genetically modified to express IL-4 reduce disease pathology in mouse models of collagen-induced arthritis and delayed-type hypersensitivity. Moreover, treatment of normoglycemic NOD mice with bone marrow derived DC, genetically modified to express interleukin 4 (IL-4), reduces the onset of hypergl...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید