Precision medicine in oncology has been a popular topic of discussion in the health-care field since US President Barack Obama announced the Precision Medicine Initiative at his 2015 State of the Union address. Precision medicine is focused on identifying which therapies are most effective for individual patients based on the genetic characterization of their cancer [1-3]. Since the late 1990s,...

Precision medicine and personalized health efforts propose leveraging complex molecular, medical and family history, along with other types of personal data toward better life. We argue that this ambitious objective will require advanced and specialized machine learning solutions. Simply skimming some low-hanging results off the data wealth might have limited potential. Instead, we need to bett...

Advances in understanding the biology of cancer, as well as advances in diagnostic technologies, such as the advent of affordable high-resolution DNA sequencing, have had a major impact on the approach to identification of specific alterations in a given patient's cancer that could be used as a basis for treatment selection, and hence the development of companion diagnostics. Although there are...