Recent RNA-seq studies reveal that the transcriptomes in animals and plants are more complex than previously thought, leading to the inclusion of many more splice isoforms in annotated genomes. However, it is possible that a significant proportion of the transcripts are spurious isoforms that do not contribute to functional proteins. One of the current hypotheses is that commonly used mRNA extr...

Mice with the scid mutation have a defect in the V(D)J recombinase. In order to determine whether the SCID product is normally present in mature B cells that do not have the recombinase activity, scid pre-B cells were fused with myeloma cells. It was found that in the hybrid cells, a rearrangement test gene was correctly joined immediately after fusion. The same test gene was aberrantly rearran...

Numerous factors direct eukaryotic ribosome biogenesis, and defects in a single ribosome assembly factor may be lethal or produce tissue-specific human ribosomopathies. Pre-ribosomal RNAs (pre-rRNAs) must be processed stepwise and at the correct subcellular locations to produce the mature rRNAs. Nop9 is a conserved small ribosomal subunit biogenesis factor, essential in yeast. Here we report a ...

Neonatal ovarian cysts (NOC) are usually self-limiting structures, however, large or complex cysts may lead to severe complications. Unfortunately, no standard guidelines have been introduced for the management, treatment and follow-up of these cysts. In this report, we aimed to introduce a very large NOC without any pre- and post-natal complications. A 30 year-old mother, gravida 2, para 2, wi...

MicroRNAs are small endogenous noncoding RNAs involved in posttranscriptional gene regulation. During microRNA biogenesis, Drosha and Dicer process the primary transcript (pri-miRNA) through a precursor hairpin (pre-miRNA) to the mature miRNA. The miRNA is incorporated into the RNA-Induced Silencing Complex (RISC) with Argonaute proteins, the effector molecules in RNA interference (RNAi). Here,...

Background. The objective was to examine the association between prepregnancy physical exercise and offspring birth weight and to assess the combined association of pre-pregnancy body mass index (BMI) and physical exercise on birth weight. Methods. The study included 2,026 women aged 20-39 years participating in the Norwegian HUNT study and linked with the Medical Birth Registry. We calculated ...

Case report A 22-year-old Caucasian primigravida in a hitherto normal 28-week pregnancy developed intermittent fever with generalized headache, facial paraesthesia, photophobia and 2 episodes of vomiting. Her parents suffered from migraine and the patient ascribed her headaches to the same cause. Her general practitioner prescribed paracetamol. She attended routine ante-natal clinic at 30 weeks...

Construction robotics is an infant discipline whose mature form is not apparent. Despite the many advantages and benefits of introducing robotic technology to the construction work site, progress to date has been circuitous. Needs, prospects, challenges, and goals of construction robotics are presented. They suggest an evolutionary approach to the development of advanced construction machines, ...

Teratomas of the central nervous system are rare and are frequently found in children and young adults. Cystic teratomas found in infancy is a well-recognized but infrequent entity. Intracranial teratomas,like teratomas in general, tend to arise from midline structures such as the pineal gland, but has rarely been found in the third ventricle. We report a rare case of a 6-month-old infant with ...