BackgroundEven though there have been tremendous strides globally in reducing the burden of tetanus, neonatal deaths due to tetanus reported annually, and most occur sub-Saharan Africa which accounts for nearly half global mortality by tetanus. Immunization pregnant women or childbearing age with at least two doses toxoid is estimated reduce from 94%. Despite its importance, immunization progra...

BACKGROUND To achieve a measles free world, effective communication must be part of all elimination plans. The choice of communication approaches must be evidence based, locally appropriate, interactive and community owned. In this article, we document the innovative approach of using house visits supported by a web-enabled mobile phone application to create a real-time platform for adaptive ma...

Neonatal immunization with hepatitis B (HB) vaccine is highly effective; however, more needs to be learned about the duration of protection and indications for boosters. We measured antibody to HB core antigen (anti-HBc), HB surface antigen (HBsAg), and pre- and postbooster titers of HBsAg antibody (anti-HBs) 15 years after primary neonatal immunization with plasma-derived HB vaccines in 2 coho...

BACKGROUND In 2002 a Meningococcal serogroup C (MenC) conjugate vaccine, with tetanus toxoid as carrier protein, was introduced in the Netherlands as a single-dose at 14 months of age. A catch-up campaign was performed targeting all individuals aged 14 months to 18 years. We determined the MenC-specific immunity before and after introduction of the MenC conjugate (MenCC) vaccine. METHODS AND ...

Vaccination considered as one of the most cost-effective health interventions worldwide  through prevention and control of many serious childhood diseases (1). It is estimated  global coverage of  Dose 3 of Diphtheria, Tetanus, and Pertussis (DTP3)among children one year old has been 86% in 2014 (by range from 77% to 96%  in African Region and Western Pacific Region; respectively) (2). Globally...

not beginning or completing the vaccination schedule as recommended in the expanded programme on immunization is one of the major reasons for low immunization coverage. it should be studied in detail for remedial action, if the objectives of the epi in iran are to be achieved as stated. generally, lack of knowledge, lack of motivation and obstacles ore the basic categorical reasons for low cove...

BACKGROUND Among the expected benefits of electronic health records (EHRs) is increased reporting of public health information, such as immunization status. State and local immunization registries aid control of vaccine-preventable diseases and help offset fragmentation in healthcare, but reporting is often slow and incomplete. The Primary Care Information Project (PCIP), an initiative of the N...

Toxoplasma gondii is known to cause congenital infection in humans and animals and severe disease in immunocompromised individuals; consequently development of vaccines against the parasite is highly necessary. Under stress conditions, T. gondii expresses the highly immunogenic heat shock protein 70 (TgHSP70). Here, we assessed the protective efficacy of rTgHSP70 immunization combined with Alum...

Replication-defective adenovirus serotype 5 (rAd5) is the most potent recombinant vector for eliciting CD8 T cell responses in humans. In this study, the innate mechanisms that influence T cell responses following rAd5 immunization were assessed in mice. Using rAd5 expressing enhanced GFP (eGFP-rAd5), we show that rAd5 transfects CD11c(+) dendritic cells (DCs) in draining lymph nodes in vivo fo...