نتایج جستجو برای: prdm16

تعداد نتایج: 242  

2012
Louis Z. Sharp Kosaku Shinoda Haruya Ohno David W. Scheel Emi Tomoda Lauren Ruiz Houchun Hu Larry Wang Zdena Pavlova Vicente Gilsanz Shingo Kajimura

Brown adipose tissue (BAT) dissipates chemical energy and generates heat to protect animals from cold and obesity. Rodents possess two types of UCP-1 positive brown adipocytes arising from distinct developmental lineages: "classical" brown adipocytes develop during the prenatal stage whereas "beige" or "brite" cells that reside in white adipose tissue (WAT) develop during the postnatal stage in...

2014
Alexey Tomilov Ahmed Bettaieb Kyoungmi Kim Sunil Sahdeo Natalia Tomilova Adam Lam Kevork Hagopian Michelle Connell Jennifer Fong Douglas Rowland Stephen Griffey Jon Ramsey Fawaz Haj Gino Cortopassi

Adipose tissue is an important metabolic organ that integrates a wide array of homeostatic processes and is crucial for whole-body insulin sensitivity and energy metabolism. Brown adipose tissue (BAT) is a key thermogenic tissue with a well-established role in energy expenditure. BAT dissipates energy and protects against both hypothermia and obesity. Thus, BAT stimulation therapy is a rational...

2016
Nan-Nan Wu Chuan-Hai Zhang Hyuek-Jong Lee Yan Ma Xin Wang Xiao-Juan Ma Wei Ma Dong Zhao Ying-Mei Feng

Both brown adipocytes (BAC) and beige cells hold therapeutic potential for the treatment of metabolic disorders. Unfortunately, the amount and activity of these cells are limited in adults. Although BAC marker expression has been shown in peri-renal adipose tissues in children and adults, functional assessment is lacking. Furthermore, it is entirely unknown whether adipose progenitors are prese...

Journal: :Blood 2011
Samuel Quentin Wendy Cuccuini Raphael Ceccaldi Olivier Nibourel Corinne Pondarre Marie-Pierre Pagès Nadia Vasquez Catherine Dubois d'Enghien Jérôme Larghero Régis Peffault de Latour Vanderson Rocha Jean-Hugues Dalle Pascale Schneider Mauricette Michallet Gérard Michel André Baruchel François Sigaux Eliane Gluckman Thierry Leblanc Dominique Stoppa-Lyonnet Claude Preudhomme Gérard Socié Jean Soulier

Fanconi anemia (FA) is a genetic condition associated with bone marrow (BM) failure, myelodysplasia (MDS), and acute myeloid leukemia (AML). We studied 57 FA patients with hypoplastic or aplastic anemia (n = 20), MDS (n = 18), AML (n = 11), or no BM abnormality (n = 8). BM samples were analyzed by karyotype, high-density DNA arrays with respect to paired fibroblasts, and by selected oncogene se...

2013
George J. Burghel Wei-Yu Lin Helen Whitehouse Ian Brock David Hammond Jonathan Bury Yvonne Stephenson Rina George Angela Cox

Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. Chromosomal instability (CIN) is a major driving force of microsatellite stable (MSS) sporadic CRC. CIN tumours are characterised by a large number of somatic chromosomal copy number aberrations (SCNA) that frequently affect oncogenes and tumour suppressor genes. The main aim of this work was to identify novel candidate CRC ...

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