نتایج جستجو برای: pparg
تعداد نتایج: 1029 فیلتر نتایج به سال:
Background Lung adenocarcinoma (LUAD) is a dominant tumor with high morbidity and mortality. In spite of innovations in surgery, chemotherapy, targeted therapies, the prognosis for patients LUAD remains unsatisfactory. Therefore, it particularly important to study biological markers occurrence, development, this disease. Methods study, 3 datasets were selected from Gene Expression Omnibus (GEO)...
Abstract The role of peroxisome proliferator activated receptor gamma (PPARg) in the regulation lipid metabolism, adipocyte differentiation and inflammatory response has been well characterized. Besides adipose tissue, PPARg is also highly expressed intestine. However, functional intestinal function still remains poorly understood. In present study we sought to understand activation on barrier ...
Background/Aim: Peroxisome proliferator-activated receptor gamma (PPARg) belongs to a family of nuclear hormone receptors and ligand-activated transcription factors. PPARG gene is expressed in many tissues including adipose tissue where it plays crucial role differentiation adipocyte, insulin resistance, blood glucose levels lipid metabolism. The aim the study was examine association rs3856806 ...
Abstract Background DHA‐H (2‐hydroxy‐docosahexaenoic acid) is a promising therapeutic approach for Alzheimer’s Disease (AD). gives rise to dose‐dependent increased levels of HPA (Heneicosapentaenoic in blood plasma and brain whereas remains virtually absent from the DHA‐H‐treated mice. Oral administration transgenic model AD (5xFAD mice) induces significative cognitive recovery. However, molecu...
The authors of the above research article have informed the journal that although the paper uses the official nomenclature PPARG to signify the peroxisome proliferator-activated receptor gamma gene, the most prevalent term used in the literature is PPARc. Therefore, the title, abstract, and keywords have been changed and now apply the latter term to improve searchability. The authors apologize ...
Obesity is a major public health problem with a significant genetic component. Multiple DNA polymorphisms/genes have been shown to be strongly associated with obesity, typically in populations of European descent. The aim of this study was to verify the extent to which 6 confirmed obesity genes (FTO, CTNNBL1, ADRB2, LEPR, PPARG and UCP2 genes) could be replicated in 8 different samples (n = 11,...
Activation of peroxisome proliferator activated receptor-gamma (PPARG) is required for the differentiation of marrow mesenchymal stem cell into adipocytes and is associated with the development of age-related marrow adiposity in mice. Thiazolidinediones are agonists for PPARG and have a heterogeneous effect on bone mineral density (BMD). We postulated that genetic determinants influence the ske...
BACKGROUND Docosahexaenoic acid (DHA), supplied by the diet or endogenous biosynthesis from α-linolenic acid, accretes during the perinatal brain growth spurt. Results regarding a potential programming effect on cognitive function and behavior in humans are inconclusive. OBJECTIVE Here we aimed to investigate whether behavioral outcomes in childhood were associated with FADS tag-single-nucleo...
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