Although it has been known for some time that a loss of potassium from the body occurs in fasting3' 18 and certain types of dehydration,5' 13 and recently that the replacement of this potassium during parenteral therapy of the dehydration due to infantile diarrhea may materially reduce the mortality rate,9 many of the changes that occur in the metabolism of potassium during the state of extreme...

The regulation of potassium metabolism involves mechanisms for the appropriate distribution between the intra- and extracellular fluid compartments and for the excretion by the kidney. Clearance and single-nephron studies show that renal excretion is determined by regulated potassium secretion and potassium reabsorption, respectively, in principal and intercalated cells of the distal nephron. M...

A study of the effect of additional oral potassium on the low body potassium of seven patients with severe valvular heart disease showed that the potassium supplements were retained. After one month's treatment the exchangeable potassium was significantly increased, but the predicted value was not reached in any of the patients. There was no significant change in plasma potassium. These results...

A potassium loading study was performed in acutely nephrectomized rats to determine the extrarenal effects of diuretics on potassium tolerance. Four diuretics were evaluated: hydrochlorothiazide, furosemide, bumetanide, and spironolactone. Following an intravenous potassium load (0.17 mEq/100 g over one hour), plasma potassium concentration rose by 2.69 +/- 0.26 to 3.67 +/- 0.20 mEq/L in all gr...

Toktam Faal Rastegar was born in Quchan (Iran). She completed her B.Sc. in Chemistry in 2005 from Ferdowsi University, Mashhad. She was graduated from M.Sc. degree in Organic Chemistry from Bu-Ali Sina University (2008), Hamadan, Iran. She is currently Organic Chemistry Ph.D student under the supervision of Prof. A. Khazaei and Prof. M.A. Zolfigol in Department of Chemistry at Bu-Ali Sina Unive...

Toktam Faal Rastegar was born in Quchan (Iran). She completed her B.Sc. in Chemistry in 2005 from Ferdowsi University, Mashhad. She was graduated from M.Sc. degree in Organic Chemistry from Bu-Ali Sina University (2008), Hamadan, Iran. She is currently Organic Chemistry Ph.D student under the supervision of Prof. A. Khazaei and Prof. M.A. Zolfigol in Department of Chemistry at Bu-Ali Sina Unive...

Extra potassium supplements, spironolactone or amiloride were given for 5 months to forty-nine patients with heart failure who were taking furosemide and were in a steady state. Plasma potassium increased with all three treatments but there was no significant increase in total body potassium or red cell potassium. These findings together with other studies suggest that patients with heart failu...

The administration of potassium to hypotensive, potassium-deficient rats results in a prompt restoration of their lowered blood pressure to noimotensive levels. Similar repletion of the potassium deficit in adrenalectomized rats is only partially effective in restoring the blood pressure to noimotensive levels. The spontaneous retention of potassium which occurs in potassium-deficient rats foll...

BACKGROUND Cardiac surgery patients are commonly treated with diuretics, which can result in hypokalemia requiring potassium supplementation. OBJECTIVE Our objective was to determine whether cardiac surgery patients receiving therapy with potassium-wasting diuretics can safely and beneficially maintain serum potassium levels by eating potassium-rich foods. DESIGN A prospectively randomized ...