The relationship between total homocysteine (tHcy) and dementia risk remains controversial, as the association varies among populations and dementia subtypes. We studied a Venezuelan population that has high prevalence of both elevated tHcy and dementia. We tested the hypotheses that (1) elevated tHcy is associated with increased dementia risk, (2) the risk is greater for vascular dementia (VaD...

Stroke patients are at a higher risk of developing progressive cognitive impairment, often retarding patient rehabilitation. Studies have been carried out to find out the molecular mechanism associated with the stroke and its consequences on the various brain regions implicated in cognitive function. The current available therapy does not improve longterm outcome and remains a substantially unm...

BACKGROUND AND PURPOSE White matter hyperintensity (WMH) volume and covert brain infarcts are highly prevalent in older adults and are often asymptomatic. We compared the impact of WMH volume and brain infarcts on risk of clinical stroke and dementia in older adults in the population. METHODS Participants were 1677 individuals aged ≥65 years from the 3-City Dijon study, who were free of strok...

BACKGROUND Depression is common and an important consequence of stroke but there is limited information on the longer-term relationship between these conditions. AIMS To identify the prevalence, incidence and predictors of depression in a secondary-care-based cohort of stroke survivors aged over 75 years, from 3 months to up to 10 years post-stroke. METHOD Depression was assessed annually b...

BACKGROUND Cognitive decline after cerebrovascular stroke has adverse outcome consequences. Since some vascular causes can be prevented and treated, the identification of stroke-related cognitive impairment is a challenge. Patients with cognitive impairment and vascular diseases exhibit higher homocysteine (Hcy) concentrations. Whether Hcy is an independent risk factor for cognitive impairment ...

See related article, pages 000–000. In this issue of Stroke, Reitz and coworkers explore the link between incident stroke and dementia in data from the Rotterdam Study.1 The emphasis on incident stroke is important: previous studies to address this question have recruited patients at the time of stroke so that prestroke cognitive status has been inferred rather than measured directly.2,3 Theref...

OBJECTIVES Cerebral white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) are a recognised risk factor for post-stroke dementia. Their specific relations to cognitive impairment are still not well known. The purpose of this study was to explore how the severity and location of WMHs predict neuropsychological test performance in the context of other brain lesions in elderly st...

Background and Purpose—It has been suggested that daily intake of aspirin is associated with a reduction of cognitive decline, both in normal and in demented subjects, but the mechanism is unclear. We have therefore studied the relationship between thromboxane (TX) A2 biosynthesis, as reflected by the urinary excretion of 11-dehydro-TXB2, and the presence of dementia in patients after acute str...

Cerebrovascular disease typically manifests with stroke, cognitive impairment, or both. Vascular cognitive impairment refers to all forms of cognitive disorder associated with cerebrovascular disease, regardless of the specific mechanisms involved. It encompasses the full range of cognitive deficits from mild cognitive impairment to dementia. In principle, any of the multiple causes of clinical...