OBJECTIVES We used acetylsalicylic acid (ASA) as a probing agent to quantify hydroxyl radical ((*)OH) in Controls and patients with coronary artery disease and to prospectively investigate (*)OH production in patients with myocardial infarction (MI) complicated by heart failure (HF). BACKGROUND Oxidative stress status (OSS) is a mechanism for transition to HF in experimental heart injury mode...

PURPOSE OF REVIEW EDTA chelation therapy has been in off-label use for the treatment of atherosclerosis. We review the results of the first large-scale randomized trial of this treatment. RECENT FINDINGS The trial to assess chelation therapy was a $30 million National Institutes of Health-funded study of the safety and efficacy of EDTA-based chelation infusions in 1708 post-myocardial infarct...

OBJECTIVE We estimated the prevalence of posttraumatic stress disorder (PTSD) and identified predictors of self-rated PTSD symptoms in patients post-myocardial infarction (MI). METHODS We recruited 400 patients (mean age 60 +/- 12 years, 79% were men) with a previous acute index MI who were referred to a tertiary cardiology clinic. PTSD was assessed by the Clinician-administered PTSD Scale, a...

BACKGROUND Coronary heart disease is the most important cause of death and inability in all communities. Depressive symptoms are frequent among post-myocardial infarction (MI) patients and may cause negative effects on cardiac prognosis. This study was conducted to identify efficacy of EMDR on depression of patients with MI. METHODS This study is a clinical trial. Sixty patients with MI were ...

Purpose: This PhD study explores the perspectives and experiences of people who do not use existing cardiac resources following a myocardial infarction (MI)y‘heart attack’, and of their family membersyfriends. How might the system of post-MI support be improved to help more people care for their heart instead of ‘voting with their feet’? Background: A large proportion of post-MI people, and par...

Background: Epidemiologic studies demonstrated that community acquired pneumonia is associated with increased risk for cardiovascular events. Type 2 MI has been shown to predict a grave outcome, but the long term outcome of patients admitted with CAP who had also type 2 MI has not been studied. Methods: during the years 2010-2016 all patients that were admitted with CAP were included in this re...

Background and Objective: Acute myocardial infarction (MI) is caused due to coronary artery occlusion and divided into two forms of ST-elevation (STEMI) and non-ST-elevation (NSTEMI) myocardial infarction. This study aimed to determine the success rate of treatment with primary PCI (percutaneous coronary intervention) versus thrombolysis in the establishment of perfusion and to evaluate the sho...

Our study aimed to investigate the gene expression at different myocardial infarction (MI) phases and to understand the development mechanisms of congestive heart failure (CHF) after MI. Dataset GSE1957 including 24 samples of rat left ventricles at 1-day post MI or sham operation and 7-day post MI or sham operation was downloaded from Gene Expression Ominibus. The data were normalized with an ...

M yocardial infarction (MI) remains one of the most common health emergencies, and a sizable fraction of acute MI patients develop subsequent complications (1). Despite guideline-adherent therapy, post-MI heart failure occurs, motivating efforts to identify patients at risk and to develop novel therapeutic strategies. Increasingly, cardiologists are looking at the immune system’s role in the re...

OBJECTIVES Posttraumatic stress disorder (PTSD) prospectively increases the risk of incident cardiovascular disease (CVD) independent of other risk factors in otherwise healthy individuals. Between 10% and 20% of patients develop PTSD related to the traumatic experience of myocardial infarction (MI). We investigated the hypothesis that PTSD symptoms caused by MI predict adverse cardiovascular o...