BACKGROUND Biochemical and physical characteristics of extracellular environment play a key role in assisting cell behavior over different molecular pathways. In this study, we investigated how the presence of chemical binding sites, the pore network and the stiffness of designed scaffolds affected prostate cancer cells. METHODS A blend of poly hydroxyethyl methacrylate-alginate-gelatin scaff...

The constitutive relation that describes the amount of nonwetting ̄uid phase entrapment is critical to the modeling of multiphase ̄ow in porous media, but it has received insucient attention in the literature. We studied this relation using both experimental and modeling approaches: we used a nondestructive, X-ray monitored, long-column experiment that yielded a rich data set for two di€erent p...

We imaged the interiors of relatively intact Xenopus oocyte nuclei by field emission scanning electron microscopy (feSEM) and visualized a network of filaments that attach to nuclear pore complexes and extend throughout the nucleus. Within the nucleus, these 'pore-linked filaments' (PLFs) were embedded into spherical structures 100 nm to approximately 5 microm in diameter. A subset of spheres w...

The bacterial cell wall is a network of sugar strands crosslinked by peptides that serve as the primary structure for bearing osmotic stress. Despite its importance in cellular survival, the robustness of the cell wall to network defects has been relatively unexplored. Treatment of the gram-negative bacterium Escherichia coli with the antibiotic vancomycin, which disrupts the crosslinking of ne...

We study the interplay of pore-scale mixing and network-scale advection through heterogeneous porous media, its role for evolution asymptotic behavior hydrodynamic dispersion. In a Lagrangian framework, we identify three fundamental mechanisms that determine large scale particle motion, namely, smoothing intra-pore velocity contrasts, increase tortuosity paths, setting maximum time transitions....

crystal. a) Preparation of porous network complex [(ZnI2)3(1)2(2a)]n. b) Single-crystal-to-single-crystal transformation of 2a into labile imine 3a in the pore of the network complex. c) Crystal structures before and after crystalline-state reaction. NW2/2006G284 Direct Observation of the Labile Imine Formation through Single-crystal-tosingle-crystal Reactions in the Pores of a Porous Coordinat...

The plant hormone abscisic acid (ABA) regulates the aperture of the stomatal pore. The recent identification of new intermediates involved in ABA signaling suggests that this complex pathway is organized as a module-based network.

In the last 3 years there has been a huge increase in the use of pore-scale modeling to study multiphase flow and transport in porous media. Starting from single pore models of fluid arrangements, computations of relative permeability, interfacial area, dissolution rate and many other physical properties have been made. Combined with a realistic description of the pore space, predictive modelin...

The concept of immiscible displacement as an invasion percolation (IP) process driven by heat and mass transfer is used in a pore network model for convective drying of capillary porous media. The coupling between heat and mass transfer occurs at the liquid-gas interface through temperature dependent equilibrium vapour pressure, surface tension and phase change enthalpy (in evaporation and cond...

Scaffolding plays pivotal role in tissue engineering. In this work, a novel processing technique has been developed to create three-dimensional biodegradable polymer scaffolds with well-controlled interconnected spherical pores. Paraffin spheres were fabricated with a dispersion method, and were bonded together through a heat treatment to form a three-dimensional assembly in a mold. Biodegradab...